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NMN (Nicotinamide Mononucleotide)

NAD+ Precursororal · inferred

Direct precursor to NAD+ via the salvage pathway. Rapidly absorbed and converted to NAD+ within 30 minutes of oral administration. NAD+ levels decline ~50% by age 60. Shown to improve insulin sensitivity, physical performance, and cellular repair in human trials.

Projected serum levels — 500 mg, once daily

NMN (Nicotinamide Mononucleotide)
NMN (Nicotinamide Mononucleotide) modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 50 100 150 200 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 500 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 126 mg, trough ≈ 4.5 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
NAD+ Precursor
Route modeled
Oral
Model confidence
inferred
Half-life
6 h
Common dose
500 mg
Suggested maximum
1k mg/day
Reference dose range
250–1k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • caution
    Berberine + NMN (Nicotinamide Mononucleotide) Potentiation

    Berberine activates AMPK, which can influence NAD+ metabolism. Some evidence suggests berberine may partially inhibit the NMNAT pathway, potentially reducing NMN conversion to NAD+.

  • caution
    Metformin + NMN (Nicotinamide Mononucleotide) Potentiation

    Metformin and NMN both affect NAD+ and AMPK pathways. Some researchers (e.g., David Sinclair) suggest metformin may blunt exercise-induced NAD+ benefits and interfere with NMN efficacy.

  • moderate
    NAD+ (IV/Injection) + NMN (Nicotinamide Mononucleotide) Stacked effects

    NAD+ (IV/Injection) and NMN (Nicotinamide Mononucleotide) both push the nad salvage pathway and sirt1 in the same direction.

  • moderate
    Nicotinamide Riboside (NR, Niagen) + NMN (Nicotinamide Mononucleotide) Stacked effects

    Nicotinamide Riboside (NR, Niagen) and NMN (Nicotinamide Mononucleotide) both push the nad salvage pathway and sirt1 in the same direction.

  • watch
    Fisetin + NMN (Nicotinamide Mononucleotide) Stacked effects

    Fisetin and NMN (Nicotinamide Mononucleotide) both push the sirt1 in the same direction.

  • watch
    Niacin (Vitamin B3) + NMN (Nicotinamide Mononucleotide) Stacked effects

    Niacin (Vitamin B3) and NMN (Nicotinamide Mononucleotide) both push the nad salvage pathway in the same direction.

Serum checks 9 modeled interaction pairings for nmn (nicotinamide mononucleotide) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Effect of Oral Administration of Nicotinamide Mononucleotide on Clinical Parameters and Nicotinamide Metabolite Levels in Healthy Japanese Men Irie J et al. · Endocrine Journal, 2020 DOI

    First human PK study of NMN (100-500 mg oral) showing safe metabolism and dose-proportional increases in NAD+ metabolites over 5 hours in healthy men.

  2. The Efficacy and Safety of Beta-Nicotinamide Mononucleotide Supplementation in Healthy Middle-Aged Adults Yi L et al. · GeroScience, 2023 DOI

    Randomized double-blind trial showing 300-900 mg/day NMN for 60 days increased blood NAD+ levels and improved physical performance in middle-aged adults.

  3. Nicotinamide Mononucleotide (NMN) as an Anti-Aging Health Product: Promises and Safety Concerns Nadeeshani H et al. · Journal of Advanced Research, 2022 DOI

    Comprehensive review of NMN biology, metabolism via the NAD+ salvage pathway, safety profile, and clinical evidence for anti-aging effects.

3 published studies referenced in the app, each with a plain-language summary.