Home › Compound Library › NAD+ (IV/Injection)

NAD+ (IV/Injection)

Peptideoral · inferred

Direct intravenous or intramuscular administration of nicotinamide adenine dinucleotide. Rapidly cleared from plasma with half-life ~14 min. IV infusions typically run 250-750 mg over 2-6 hours due to nausea/flushing at faster rates. Directly replenishes cellular NAD+ pools without requiring precursor conversion. Distinct from oral NMN/NR supplementation.

Projected serum levels — 250 mg, weekly

NAD+ (IV/Injection)
NAD+ (IV/Injection) modeled serum levels, 250 mg weekly over 21 days Population-based pharmacokinetic estimate. Steady state reached after approximately 7 days. 0 25 50 75 100 Day 0 Day 5 Day 11 Day 16 Day 21 Time on a regular schedule ≈ steady state · day 7

Maintenance schedule: 250 mg weekly (oral).

Modeled steady state after ~7 days: peak ≈ 79.0 mg, trough ≈ 0.000 mg body load. Population-based estimate over 21 days for a 250 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
Oral
Model confidence
inferred
Half-life
2.7 h
Common dose
250 mg
Suggested maximum
750 mg/day
Reference dose range
125–750 mg (single dose)
Suggested cadence
weekly

Documented interactions

  • moderate
    Nicotinamide Riboside (NR, Niagen) + NAD+ (IV/Injection) Stacked effects

    NAD+ (IV/Injection) and Nicotinamide Riboside (NR, Niagen) both push the nad salvage pathway and sirt1 in the same direction.

  • moderate
    NMN (Nicotinamide Mononucleotide) + NAD+ (IV/Injection) Stacked effects

    NAD+ (IV/Injection) and NMN (Nicotinamide Mononucleotide) both push the nad salvage pathway and sirt1 in the same direction.

  • watch
    Fisetin + NAD+ (IV/Injection) Stacked effects

    Fisetin and NAD+ (IV/Injection) both push the sirt1 in the same direction.

  • watch
    Niacin (Vitamin B3) + NAD+ (IV/Injection) Stacked effects

    NAD+ (IV/Injection) and Niacin (Vitamin B3) both push the nad salvage pathway in the same direction.

  • watch
    Quercetin + NAD+ (IV/Injection) Stacked effects

    NAD+ (IV/Injection) and Quercetin both push the sirt1 in the same direction.

  • watch
    Resveratrol (trans-Resveratrol) + NAD+ (IV/Injection) Stacked effects

    NAD+ (IV/Injection) and Resveratrol (trans-Resveratrol) both push the sirt1 in the same direction.

Serum checks 7 modeled interaction pairings for nad+ (iv/injection) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+ Grant R et al. · Frontiers in Aging Neuroscience, 2019 DOI

    First human IV NAD+ pharmacokinetic study showing no change in plasma NAD+ until 2 hours into a 6-hour infusion, with significant increases in NAD+ metabolites (methylnicotinamide, ADPR) in plasma and urine.

  2. High-dose intravenous glutathione in man: pharmacokinetics and effects on cyst(e)ine in plasma and urine Aebi S et al. · European Journal of Clinical Investigation, 1991 DOI

    Pharmacokinetic study of high-dose IV infusions establishing rapid plasma clearance kinetics relevant to understanding IV delivery of endogenous metabolites including NAD+.

2 published studies referenced in the app, each with a plain-language summary.