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Spermidine

Polyamineoral · inferred

Natural polyamine that induces autophagy and promotes cellular renewal. Found in wheat germ, aged cheese, and soybeans. Intracellular half-life ~15 hours. Levels decline with age. Associated with reduced cardiovascular mortality and improved cognitive function in epidemiological studies.

Projected serum levels — 6 mg, once daily

Spermidine
Spermidine modeled serum levels, 6 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 6 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 0.24 mg, trough ≈ 0.023 mg body load. Population-based estimate over 15 days for a 6 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Polyamine
Route modeled
Oral
Model confidence
inferred
Half-life
6 h
Common dose
6 mg
Suggested maximum
15 mg/day
Reference dose range
3–15 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • watch
    Urolithin A (Mitopure) + Spermidine Stacked effects

    Spermidine and Urolithin A (Mitopure) both push the autophagy pathway in the same direction.

Serum checks 1 modeled interaction pairings for spermidine across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Spermidine: A Physiological Autophagy Inducer Acting as an Anti-Aging Vitamin in Humans? Madeo F et al. · Autophagy, 2019 DOI

    Review establishing spermidine as a caloric restriction mimetic that induces autophagy, with epidemiological data linking dietary intake to reduced all-cause mortality.

  2. High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults Senekowitsch S et al. · Nutrients, 2023 DOI

    First randomized placebo-controlled PK study of oral spermidine (15 mg/day) showing tight homeostatic control of plasma polyamine levels despite supplementation.

  3. Safety and Tolerability of Spermidine Supplementation in Mice and Older Adults with Subjective Cognitive Decline Schwarz C et al. · Aging, 2018 DOI

    Phase II trial demonstrating safety and tolerability of spermidine supplementation in older adults with subjective cognitive decline over 3 months.

  4. Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial. Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D, Wirth M, Madeo F, Flöel A · JAMA network open, 2022 DOI

    This citation reports a human clinical study involving Spermidine. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.