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Apigenin

Flavonoidoral · inferred

Flavonoid found in chamomile and parsley. Inhibits CD38 (an NAD+-consuming enzyme), thereby increasing NAD+ levels. Also acts as a mild anxiolytic and sleep aid via GABA modulation. Potent anti-inflammatory and potential cancer-preventive properties.

Projected serum levels — 50 mg, once daily

Apigenin
Apigenin modeled serum levels, 50 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 1.3 2.5 3.8 5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 50 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 4.8 mg, trough ≈ 0.037 mg body load. Population-based estimate over 15 days for a 50 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Flavonoid
Route modeled
Oral
Model confidence
inferred
Half-life
3 h
Common dose
50 mg
Suggested maximum
100 mg/day
Reference dose range
25–100 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    Caffeine + Apigenin CYP inhibition

    Apigenin reversible_inhibitor of CYP1A2 predicted to change Caffeine AUC by ~2.99x

  • danger
    Ciprofloxacin (Cipro) + Apigenin CYP inhibition

    Apigenin reversible_inhibitor of CYP1A2 predicted to change Ciprofloxacin (Cipro) AUC by ~2.11x

  • danger
    Levothyroxine (Synthroid) + Apigenin Protein binding

    Apigenin may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration changes…

  • danger
    Melatonin + Apigenin CYP inhibition

    Apigenin reversible_inhibitor of CYP1A2 predicted to change Melatonin AUC by ~2.97x

  • danger
    Pseudoephedrine (Sudafed) + Apigenin CYP inhibition

    Apigenin reversible_inhibitor of CYP1A2 predicted to change Pseudoephedrine (Sudafed) AUC by ~3.33x

  • danger
    Rasagiline (Azilect) + Apigenin CYP inhibition

    Apigenin reversible_inhibitor of CYP1A2 predicted to change Rasagiline (Azilect) AUC by ~3.33x

Serum checks 205 modeled interaction pairings for apigenin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Apigenin and Naringenin Are Natural Inhibitors of CD38 Escande C et al. · Nature Chemical Biology, 2013 DOI

    Identified apigenin as a natural CD38 inhibitor that increases NAD+ levels in vivo, linking dietary flavonoid intake to NAD+ metabolism.

  2. A Review of the Pharmacological Effects of the Dried Root of Polygonum Cuspidatum (Hu Zhang) and Its Constituents Salehi B et al. · Phytotherapy Research, 2019 DOI

    Reviewed apigenin pharmacology including anxiolytic activity via GABA-A receptor modulation, anti-inflammatory effects, and ~12-hour elimination half-life.

  3. Apigenin: A Promising Molecule for Cancer Prevention Shukla S, Gupta S · Pharmaceutical Research, 2010 DOI

    Comprehensive review of apigenin anticancer mechanisms including cell cycle arrest, autophagy induction, and immune modulation with favorable toxicology profile.

  4. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN · Diabetes, 2013 DOI

    This citation reports a laboratory or cell study involving Apigenin. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.