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Quercetin

Polyphenoloral · inferred

Flavonoid with anti-inflammatory, antihistamine, and senolytic properties. Found in onions, apples, and berries. Bioavailability enhanced by vitamin C and bromelain.

Projected serum levels — 500 mg, once daily

Quercetin
Quercetin modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.50 1 1.5 2 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 500 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 1.6 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Polyphenol
Route modeled
Oral
Model confidence
inferred
Half-life
24 min
Common dose
500 mg
Suggested maximum
1k mg/day
Reference dose range
250–1k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Quercetin CYP inhibition

    Quercetin reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Alfuzosin (Uroxatral) + Quercetin CYP inhibition

    Quercetin reversible_inhibitor of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~3.33x

  • danger
    Alprazolam (Xanax) + Quercetin CYP inhibition

    Quercetin reversible_inhibitor of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~3.33x

  • danger
    Amlodipine (Norvasc) + Quercetin CYP inhibition

    Quercetin reversible_inhibitor of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~3.33x

  • danger
    Anastrozole (Arimidex) + Quercetin CYP inhibition

    Quercetin reversible_inhibitor of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~2.68x

  • danger
    Astaxanthin + Quercetin CYP inhibition

    Quercetin reversible_inhibitor of CYP3A4 predicted to change Astaxanthin AUC by ~3.33x

Serum checks 493 modeled interaction pairings for quercetin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. The combination of dasatinib and quercetin as a senolytic therapy reduces adipose tissue senescent cells and improves physical function in humans Hickson LJ et al. · EBioMedicine, 2019 DOI

    First-in-human pilot study showing the senolytic combination of dasatinib plus quercetin reduced senescent cell burden and improved physical function in patients with diabetic kidney disease.

  2. Quercetin and its anti-allergic immune response Mlcek J et al. · Molecules, 2016 DOI

    Review of quercetin antihistamine mechanisms showing it stabilizes mast cells, inhibits histamine release, and reduces pro-inflammatory cytokines relevant to allergic conditions.

2 published studies referenced in the app, each with a plain-language summary.