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Fisetin

Senolyticoral · inferred

Flavonoid senolytic found in strawberries and apples. Most potent natural senolytic tested, selectively clearing senescent cells via a "hit-and-run" mechanism. Low oral bioavailability (~44%) due to rapid metabolism. Typically used in intermittent high-dose protocols (2 consecutive days/month).

Projected serum levels — 500 mg, once daily

Fisetin
Fisetin modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 50 100 150 200 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 500 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 121 mg, trough ≈ 0.21 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Senolytic
Route modeled
Oral
Model confidence
inferred
Half-life
2.3 h
Common dose
500 mg
Suggested maximum
2k mg/day
Reference dose range
250–2k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Fisetin CYP inhibition

    Fisetin reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Alfuzosin (Uroxatral) + Fisetin CYP inhibition

    Fisetin reversible_inhibitor of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~3.33x

  • danger
    Alprazolam (Xanax) + Fisetin CYP inhibition

    Fisetin reversible_inhibitor of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~3.33x

  • danger
    Amlodipine (Norvasc) + Fisetin CYP inhibition

    Fisetin reversible_inhibitor of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~3.33x

  • danger
    Anastrozole (Arimidex) + Fisetin CYP inhibition

    Fisetin reversible_inhibitor of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~2.68x

  • danger
    Astaxanthin + Fisetin CYP inhibition

    Fisetin reversible_inhibitor of CYP3A4 predicted to change Astaxanthin AUC by ~3.33x

Serum checks 331 modeled interaction pairings for fisetin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Fisetin Is a Senotherapeutic That Extends Health and Lifespan Yousefzadeh MJ et al. · EBioMedicine, 2018 DOI

    Landmark study identifying fisetin as the most potent senolytic among 10 flavonoids tested, extending median lifespan by ~10% in mice even when administered late in life.

  2. Intermittent Supplementation with Fisetin Improves Arterial Function in Old Mice by Decreasing Cellular Senescence Mahoney SA et al. · Aging Cell, 2024 DOI

    Intermittent fisetin (500 mg/kg, 2 consecutive days biweekly) reversed age-related arterial dysfunction by clearing senescent cells and reducing SASP factors.

  3. The Effects of Fisetin on Reducing Biological Aging: A Pilot Study Justice JN et al. · Aging, 2024 DOI

    Pilot human trial of intermittent oral fisetin showing reduction in markers of biological aging and senescence with acceptable safety profile.

3 published studies referenced in the app, each with a plain-language summary.