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Resveratrol (trans-Resveratrol)

Polyphenoloral · inferred

Polyphenol found in red wine and grapes. Activates SIRT1 and AMPK pathways. Well absorbed but rapidly metabolized to glucuronide and sulfate conjugates, limiting bioavailability.

Projected serum levels — 500 mg, once daily

Resveratrol (trans-Resveratrol)
Resveratrol (trans-Resveratrol) modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 1.3 2.5 3.8 5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 500 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 3.6 mg, trough ≈ 0.023 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Polyphenol
Route modeled
Oral
Model confidence
inferred
Half-life
3 h
Common dose
500 mg
Suggested maximum
1.5k mg/day
Reference dose range
250–1.5k mg (single dose)
Suggested cadence
once daily
Validated against
500 mg oral — Cmax 0.072 mg/L at 1.5 h

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Resveratrol (trans-Resveratrol) CYP inhibition

    Resveratrol (trans-Resveratrol) reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Alfuzosin (Uroxatral) + Resveratrol (trans-Resveratrol) CYP inhibition

    Resveratrol (trans-Resveratrol) reversible_inhibitor of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~3.33x

  • danger
    Alprazolam (Xanax) + Resveratrol (trans-Resveratrol) CYP inhibition

    Resveratrol (trans-Resveratrol) reversible_inhibitor of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~3.33x

  • danger
    Amlodipine (Norvasc) + Resveratrol (trans-Resveratrol) CYP inhibition

    Resveratrol (trans-Resveratrol) reversible_inhibitor of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~3.33x

  • danger
    Anastrozole (Arimidex) + Resveratrol (trans-Resveratrol) CYP inhibition

    Resveratrol (trans-Resveratrol) reversible_inhibitor of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~2.68x

  • danger
    Astaxanthin + Resveratrol (trans-Resveratrol) CYP inhibition

    Resveratrol (trans-Resveratrol) reversible_inhibitor of CYP3A4 predicted to change Astaxanthin AUC by ~3.33x

Serum checks 271 modeled interaction pairings for resveratrol (trans-resveratrol) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients Brasnyo P et al. · British Journal of Nutrition, 2011 DOI

    RCT found resveratrol (10 mg/day for 4 weeks) improved insulin sensitivity, reduced oxidative stress, and activated the Akt pathway in type 2 diabetic patients.

  2. Resveratrol and health - a comprehensive review of human clinical trials Berman AY et al. · Molecular Nutrition & Food Research, 2017 DOI

    Comprehensive review of 29 clinical trials finding resveratrol shows promise for diabetes, cardiovascular disease, and neurological conditions, but bioavailability remains a major challenge.

  3. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Howitz KT et al. · Nature, 2003 DOI

    Groundbreaking study identifying resveratrol as a potent activator of sirtuin deacetylases (SIRT1), extending yeast lifespan by 70% and connecting sirtuins to caloric restriction benefits.

3 published studies referenced in the app, each with a plain-language summary.