Ca-AKG (Calcium Alpha-Ketoglutarate)
Calcium salt of alpha-ketoglutarate, a key Krebs cycle intermediate. Levels decline ~10x from age 40 to 80. In mice, extended median lifespan by 12% and compressed morbidity. May influence epigenetic age through TET enzyme activity (demethylation).
Projected serum levels — 1k mg, once daily
Maintenance schedule: 1k mg once daily (oral).
Modeled steady state after ~1 days: peak ≈ 327 mg, trough ≈ 3.1 mg body load. Population-based estimate over 15 days for a 1k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Longevity
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 3.1 h
- Common dose
- 1k mg
- Suggested maximum
- 2k mg/day
- Reference dose range
- 500–2k mg (single dose)
- Suggested cadence
- once daily
Research behind this entry
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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
CaAKG extended median lifespan by 12% in female mice, reduced frailty by 46%, and decreased epigenetic age, establishing AKG as a longevity-promoting metabolite.
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Rejuvant, a Potential Life-Extending Compound Formulation with Alpha-Ketoglutarate and Vitamins, Conferred an Average 8 Year Reduction in Biological Aging
Open-label human trial showing CaAKG plus vitamins A and D reduced biological age by average 8 years as measured by DNA methylation clocks over 7 months.
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Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use
Review of AKG pleiotropic effects including wound healing, immune support, bone health, and nitrogen metabolism, establishing the biochemical basis for supplementation.
3 published studies referenced in the app, each with a plain-language summary.