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Nicotinamide Riboside (NR, Niagen)

NAD+ Precursororal · inferred

Vitamin B3 analog and NAD+ precursor that bypasses NAMPT-limited salvage pathway via NRK1/2 phosphorylation. Shown to raise blood and tissue NAD+ in humans in a dose-dependent manner across multiple RCTs. Used for healthy aging, mitochondrial support, and metabolic health at 300-1000 mg/day. GRAS-designated; primary commercial form is Niagen. Competitor/alternative to NMN with more extensive human pharmacokinetic data.

Projected serum levels — 300 mg, once daily

Nicotinamide Riboside (NR, Niagen)
Nicotinamide Riboside (NR, Niagen) modeled serum levels, 300 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 50 100 150 200 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 300 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 134 mg, trough ≈ 10.6 mg body load. Population-based estimate over 15 days for a 300 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
NAD+ Precursor
Route modeled
Oral
Model confidence
inferred
Half-life
6 h
Common dose
300 mg
Suggested maximum
1k mg/day
Reference dose range
150–1k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • moderate
    NAD+ (IV/Injection) + Nicotinamide Riboside (NR, Niagen) Stacked effects

    NAD+ (IV/Injection) and Nicotinamide Riboside (NR, Niagen) both push the nad salvage pathway and sirt1 in the same direction.

  • moderate
    NMN (Nicotinamide Mononucleotide) + Nicotinamide Riboside (NR, Niagen) Stacked effects

    Nicotinamide Riboside (NR, Niagen) and NMN (Nicotinamide Mononucleotide) both push the nad salvage pathway and sirt1 in the same direction.

  • watch
    Fisetin + Nicotinamide Riboside (NR, Niagen) Stacked effects

    Fisetin and Nicotinamide Riboside (NR, Niagen) both push the sirt1 in the same direction.

  • watch
    Niacin (Vitamin B3) + Nicotinamide Riboside (NR, Niagen) Stacked effects

    Niacin (Vitamin B3) and Nicotinamide Riboside (NR, Niagen) both push the nad salvage pathway in the same direction.

  • watch
    Quercetin + Nicotinamide Riboside (NR, Niagen) Stacked effects

    Nicotinamide Riboside (NR, Niagen) and Quercetin both push the sirt1 in the same direction.

  • watch
    Resveratrol (trans-Resveratrol) + Nicotinamide Riboside (NR, Niagen) Stacked effects

    Nicotinamide Riboside (NR, Niagen) and Resveratrol (trans-Resveratrol) both push the sirt1 in the same direction.

Serum checks 7 modeled interaction pairings for nicotinamide riboside (nr, niagen) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans Trammell SAJ et al. · Nature Communications, 2016 DOI

    First human PK study of NR showing single oral doses of 100, 300, and 1000 mg dose-dependently increased blood NAD+ levels over 24 hours without flushing, establishing oral bioavailability in humans.

  2. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Martens CR et al. · Nature Communications, 2018 DOI

    Placebo-controlled crossover RCT in 30 healthy older adults found 6 weeks of 1000 mg/day NR was well-tolerated and approximately doubled blood NAD+ levels with trends toward lower blood pressure.

  3. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men Dollerup OL et al. · American Journal of Clinical Nutrition, 2018 DOI

    12-week RCT of 1000 mg BID NR in obese, insulin-resistant men found elevated NAD+ metabolites but no significant improvement in insulin sensitivity or mitochondrial function, tempering metabolic claims.

3 published studies referenced in the app, each with a plain-language summary.