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Vitamin D3 (Cholecalciferol)

Vitaminoral · inferred

Fat-soluble vitamin essential for calcium absorption, bone health, and immune function. Most people are deficient, especially in northern latitudes.

Projected serum levels — 2k IU (≈ 0.050 mg), once daily

Vitamin D3 (Cholecalciferol) (precursor)
Vitamin D3 (Cholecalciferol) modeled serum levels, 2k IU (≈ 0.050 mg) once daily over 121 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 30 Day 61 Day 91 Day 121 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 2k IU (≈ 0.050 mg) once daily (oral).

Modeled steady state after ~1 days: peak ≈ 0.002 mg, trough ≈ 0.000 mg body load. Population-based estimate over 121 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Vitamin
Route modeled
Oral
Model confidence
inferred
Half-life
30 days
Common dose
2k IU (≈ 0.050 mg)
Suggested maximum
10k IU/day
Reference dose range
400–10k IU (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    Levothyroxine (Synthroid) + Vitamin D3 (Cholecalciferol) Protein binding

    Vitamin D3 (Cholecalciferol) may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free…

  • warning
    Apigenin + Vitamin D3 (Cholecalciferol) Protein binding

    Apigenin may displace Vitamin D3 (Cholecalciferol) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Aripiprazole (Abilify) + Vitamin D3 (Cholecalciferol) Protein binding

    Aripiprazole (Abilify) may displace Vitamin D3 (Cholecalciferol) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Armour Thyroid (Desiccated Thyroid Extract) + Vitamin D3 (Cholecalciferol) Protein binding

    Vitamin D3 (Cholecalciferol) may displace Armour Thyroid (Desiccated Thyroid Extract) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Astaxanthin + Vitamin D3 (Cholecalciferol) Protein binding

    Astaxanthin may displace Vitamin D3 (Cholecalciferol) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Atomoxetine (Strattera) + Vitamin D3 (Cholecalciferol) Protein binding

    Atomoxetine (Strattera) may displace Vitamin D3 (Cholecalciferol) from plasma protein binding sites, transiently raising free drug concentration.

Serum checks 139 modeled interaction pairings for vitamin d3 (cholecalciferol) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials Autier P et al. · Archives of Internal Medicine, 2007 DOI

    Meta-analysis of 18 RCTs found that vitamin D supplementation was associated with a significant reduction in total mortality.

  2. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline Holick MF et al. · Journal of Clinical Endocrinology & Metabolism, 2011 DOI

    Landmark clinical guideline establishing vitamin D deficiency thresholds and recommending supplementation doses for various populations.

  3. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial Lappe JM et al. · American Journal of Clinical Nutrition, 2007 DOI

    RCT in postmenopausal women found that vitamin D3 plus calcium supplementation substantially reduced all-cancer risk over 4 years.

  4. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis Tripkovic L et al. · American Journal of Clinical Nutrition, 2012 DOI

    This meta-analysis of direct adult comparisons found that vitamin D3 raised total serum 25-hydroxyvitamin D more than vitamin D2 overall, driven by bolus-dose studies. The difference was not statistically significant in…

5 published studies referenced in the app, each with a plain-language summary.