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Magnesium Glycinate

Mineraloral · inferred

Highly bioavailable form of magnesium. Supports muscle and nerve function, sleep quality, and energy production. Over 50% of adults are deficient.

Projected serum levels — 400 mg, once daily

Magnesium Glycinate
Magnesium Glycinate modeled serum levels, 400 mg once daily over 121 days Population-based pharmacokinetic estimate. Steady state reached after approximately 91 days. 0 2.5k 5k 7.5k 10k Day 0 Day 30 Day 61 Day 91 Day 121 Time on a regular schedule ≈ steady state · day 91
Magnesium Glycinate modeled serum levels with a loading dose of 1.2k mg, then 400 mg once daily The first dose is larger so levels approach steady state faster. 0 2.5k 5k 7.5k 10k Day 0 Day 30 Day 61 Day 91 Day 121 Time on a regular schedule

Maintenance schedule: 400 mg once daily (oral).

Loading schedule: 1.2k mg on day 1, then 400 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~91 days: peak ≈ 7.3k mg, trough ≈ 7.2k mg body load. Population-based estimate over 121 days for a 400 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Mineral
Route modeled
Oral
Model confidence
inferred
Half-life
42 days
Common dose
400 mg
Suggested maximum
800 mg/day
Reference dose range
200–800 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • caution
    Alendronate (Fosamax) + Magnesium Glycinate Chelation

    Alendronate (Fosamax) (bisphosphonate) forms insoluble complexes with Magnesium Glycinate in the GI tract, reducing absorption of both.

  • caution
    Armour Thyroid (Desiccated Thyroid Extract) + Magnesium Glycinate Chelation

    Armour Thyroid (Desiccated Thyroid Extract) (thyroid hormone) forms insoluble complexes with Magnesium Glycinate in the GI tract, reducing absorption of both.

  • caution
    Caffeine + Magnesium Glycinate Depletion

    Caffeine increases urinary magnesium excretion. Heavy coffee intake can contribute to magnesium deficiency.

  • caution
    Calcium (Citrate) + Magnesium Glycinate Absorption

    Calcium and magnesium compete for absorption via shared intestinal transport pathways. High-dose calcium can reduce magnesium uptake.

  • caution
    Ciprofloxacin (Cipro) + Magnesium Glycinate Chelation

    Ciprofloxacin (Cipro) (fluoroquinolone antibiotic) forms insoluble complexes with Magnesium Glycinate in the GI tract, reducing absorption of both.

  • caution
    Combined OC (Levonorgestrel / Ethinyl Estradiol) + Magnesium Glycinate Depletion

    Combined OCs increase urinary magnesium excretion.

Serum checks 14 modeled interaction pairings for magnesium glycinate across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Bioavailability of magnesium diglycinate versus magnesium oxide in patients with ileal resection Schuette SA et al. · Journal of Parenteral and Enteral Nutrition, 1994 DOI

    Stable-isotope crossover study in patients with ileal resection compared magnesium diglycinate with magnesium oxide. Overall absorption did not establish universal superiority, but diglycinate was better tolerated and…

  2. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis DiNicolantonio JJ et al. · Open Heart, 2018 DOI

    Review estimating that up to 50% of Americans are magnesium deficient and linking subclinical deficiency to hypertension, cardiovascular disease, and metabolic syndrome.

  3. Oral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertension Hatzistavri LS et al. · American Journal of Hypertension, 2009 DOI

    RCT demonstrated that oral magnesium supplementation (600 mg/day) for one month significantly reduced both systolic and diastolic ambulatory blood pressure.

3 published studies referenced in the app, each with a plain-language summary.