Magnesium L-Threonate (Magtein)
Patented magnesium form (Magtein) specifically developed to cross the blood-brain barrier. L-threonate is transported via glucose transporters, enabling significant increases in brain magnesium that other forms cannot achieve. Primarily used for cognitive function, memory, and sleep rather than general magnesium supplementation. 2g provides ~144 mg elemental magnesium.
Projected serum levels — 2k mg, once daily
Maintenance schedule: 2k mg once daily (oral).
Loading schedule: 6k mg on day 1, then 2k mg once daily — reaching therapeutic levels sooner.
Modeled steady state after ~91 days: peak ≈ 41.8k mg, trough ≈ 41.4k mg body load. Population-based estimate over 121 days for a 2k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Mineral
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 42 days
- Common dose
- 2k mg
- Suggested maximum
- 4k mg/day
- Reference dose range
- 1k–4k mg (single dose)
- Suggested cadence
- once daily
Documented interactions
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caution
Alendronate (Fosamax) + Magnesium L-Threonate (Magtein)
Alendronate (Fosamax) (bisphosphonate) forms insoluble complexes with Magnesium L-Threonate (Magtein) in the GI tract, reducing absorption of both.
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caution
Armour Thyroid (Desiccated Thyroid Extract) + Magnesium L-Threonate (Magtein)
Armour Thyroid (Desiccated Thyroid Extract) (thyroid hormone) forms insoluble complexes with Magnesium L-Threonate (Magtein) in the GI tract, reducing absorption of both.
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caution
Calcium (Citrate) + Magnesium L-Threonate (Magtein)
Calcium and magnesium compete for absorption. However, magnesium threonate uses a distinct neuronal pathway for brain delivery.
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caution
Ciprofloxacin (Cipro) + Magnesium L-Threonate (Magtein)
Ciprofloxacin (Cipro) (fluoroquinolone antibiotic) forms insoluble complexes with Magnesium L-Threonate (Magtein) in the GI tract, reducing absorption of both.
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caution
Doxycycline + Magnesium L-Threonate (Magtein)
Doxycycline (tetracycline antibiotic) forms insoluble complexes with Magnesium L-Threonate (Magtein) in the GI tract, reducing absorption of both.
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caution
Levofloxacin + Magnesium L-Threonate (Magtein)
Levofloxacin (fluoroquinolone antibiotic) forms insoluble complexes with Magnesium L-Threonate (Magtein) in the GI tract, reducing absorption of both.
Serum checks 10 modeled interaction pairings for magnesium l-threonate (magtein) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.
Research behind this entry
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A Magtein, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
Double-blind RCT in 109 adults showed Magtein-based formula significantly improved all five subcategories of clinical memory testing and overall memory quotient vs control.
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Magnesium-L-Threonate Improves Sleep Quality and Daytime Functioning in Adults with Self-Reported Sleep Problems
In an 80-person, 21-day randomized trial, 1 g/day magnesium L-threonate improved several secondary subjective and Oura-derived sleep and daytime-function measures versus placebo. The primary Insomnia Severity Index…
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Safety of Magnesium L-Threonate as a Novel Food Pursuant to Regulation (EU) 2015/2283 and Bioavailability of Magnesium from This Source
EFSA safety assessment confirming magnesium bioavailability from L-threonate and establishing safety at proposed use levels based on human and animal data.
3 published studies referenced in the app, each with a plain-language summary.