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Omega-3 (EPA/DHA Fish Oil)

Fatty Acidoral · inferred

Essential fatty acids supporting cardiovascular health, brain function, and inflammation reduction. Most Western diets are deficient.

Projected serum levels — 1k mg, once daily

Omega-3 (EPA/DHA Fish Oil)
Omega-3 (EPA/DHA Fish Oil) modeled serum levels, 1k mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1k mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 373 mg, trough ≈ 9.9 mg body load. Population-based estimate over 15 days for a 1k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Fatty Acid
Route modeled
Oral
Model confidence
inferred
Half-life
2.8 h
Common dose
1k mg
Suggested maximum
5k mg/day
Reference dose range
500–5k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    Levothyroxine (Synthroid) + Omega-3 (EPA/DHA Fish Oil) Protein binding

    Omega-3 (EPA/DHA Fish Oil) may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free…

  • warning
    Apigenin + Omega-3 (EPA/DHA Fish Oil) Protein binding

    Apigenin may displace Omega-3 (EPA/DHA Fish Oil) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Aripiprazole (Abilify) + Omega-3 (EPA/DHA Fish Oil) Protein binding

    Aripiprazole (Abilify) may displace Omega-3 (EPA/DHA Fish Oil) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Armour Thyroid (Desiccated Thyroid Extract) + Omega-3 (EPA/DHA Fish Oil) Protein binding

    Omega-3 (EPA/DHA Fish Oil) may displace Armour Thyroid (Desiccated Thyroid Extract) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Astaxanthin + Omega-3 (EPA/DHA Fish Oil) Protein binding

    Astaxanthin may displace Omega-3 (EPA/DHA Fish Oil) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Atomoxetine (Strattera) + Omega-3 (EPA/DHA Fish Oil) Protein binding

    Atomoxetine (Strattera) may displace Omega-3 (EPA/DHA Fish Oil) from plasma protein binding sites, transiently raising free drug concentration.

Serum checks 152 modeled interaction pairings for omega-3 (epa/dha fish oil) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia (REDUCE-IT) Bhatt DL et al. · New England Journal of Medicine, 2019 DOI

    Landmark trial of 8,179 patients found high-dose EPA (4g/day) reduced cardiovascular events by 25% compared to placebo in statin-treated patients with elevated triglycerides.

  2. Marine omega-3 fatty acids and prevention of cardiovascular disease and cancer (VITAL) Manson JE et al. · New England Journal of Medicine, 2019 DOI

    Large RCT of 25,871 participants found omega-3 supplementation reduced heart attacks by 28% and total cardiovascular events in those with low fish intake.

  3. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression Sublette ME et al. · Journal of Clinical Psychiatry, 2011 DOI

    Meta-analysis found EPA-predominant omega-3 supplements significantly reduced depressive symptoms, with formulations containing at least 60% EPA being most effective.

3 published studies referenced in the app, each with a plain-language summary.