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7-Hydroxymitragynine (7-OH)

Opioidoral · inferred

Potent opioid agonist found in kratom (Mitragyna speciosa). ~13-46x more potent than mitragynine at mu-opioid receptors and ~10x more potent than morphine in antinociception assays. Often sold as concentrated extract or semi-synthetic product. Metabolized hepatically via CYP3A4. Significant addiction and overdose potential, especially in concentrated form. Withdrawal profile similar to traditional opioids. Much more dangerous than whole-leaf kratom due to isolated high-potency mu-agonism.

Projected serum levels — 1 mg, as needed (shown daily)

7-Hydroxymitragynine (7-OH)
7-Hydroxymitragynine (7-OH) modeled serum levels, 1 mg as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1 mg as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 0.37 mg, trough ≈ 0.009 mg body load. Population-based estimate over 15 days for a 1 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Opioid
Route modeled
Oral
Model confidence
inferred
Half-life
4 h
Common dose
1 mg
Reference dose range
0.50–2 mg (single dose)
Suggested cadence
as needed (shown daily)
Validated against
2 mg oral — Cmax 0.011 mg/L at 1.8 h

Documented interactions

  • contraindicated
    Efavirenz (Sustiva) + 7-Hydroxymitragynine (7-OH) CYP induction

    Efavirenz (Sustiva) inducer of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~0.16x

  • contraindicated
    Rifampin + 7-Hydroxymitragynine (7-OH) CYP induction

    Rifampin inducer of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~0.16x

  • danger
    Alprazolam (Xanax) + 7-Hydroxymitragynine (7-OH) Contraindicated

    Benzodiazepines combined with potent mu-opioid agonists like 7-hydroxymitragynine produce synergistic respiratory depression. Alprazolam has rapid onset which compounds the danger.

  • danger
    Amlodipine (Norvasc) + 7-Hydroxymitragynine (7-OH) CYP inhibition

    Amlodipine (Norvasc) reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Ashwagandha (KSM-66) + 7-Hydroxymitragynine (7-OH) CYP inhibition

    Ashwagandha (KSM-66) reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Berberine + 7-Hydroxymitragynine (7-OH) CYP inhibition

    Berberine reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

Serum checks 107 modeled interaction pairings for 7-hydroxymitragynine (7-oh) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats Obeng S et al. · Journal of Pharmacology and Experimental Therapeutics, 2021 DOI

    Established that 7-hydroxymitragynine has 9-fold higher affinity than mitragynine at human mu-opioid receptors and acts as a partial agonist. In vivo antinociception assays showed 7-OH is 40-fold more potent than…

  2. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects Kruegel AC et al. · ACS Central Science, 2019 DOI

    Demonstrated that mitragynine is hepatically converted to 7-hydroxymitragynine via CYP3A isoforms, and that this metabolite is the primary mediator of kratom analgesic effects. Critical to understanding kratom…

  3. Human Mitragynine and 7-Hydroxymitragynine Pharmacokinetics after Single and Multiple Daily Doses of Oral Encapsulated Dried Kratom Leaf Powder Tanna RS et al. · Molecules, 2024 DOI

    Randomized, double-blind, placebo-controlled dose-escalation study measuring plasma mitragynine and 7-hydroxymitragynine concentrations after single and 15 daily doses of kratom in healthy volunteers. Characterized…

3 published studies referenced in the app, each with a plain-language summary.