Propranolol (Inderal)
Non-selective beta-adrenergic blocker used for hypertension, essential tremor, performance anxiety, and migraine prophylaxis. Highly lipophilic with extensive first-pass metabolism; oral bioavailability ~25%. Also used off-label for anxiety-related tremor and situational anxiety.
Projected serum levels — 40 mg, twice daily
Maintenance schedule: 40 mg twice daily (oral).
Modeled steady state after ~1 days: peak ≈ 8.8 mg, trough ≈ 1.6 mg body load. Population-based estimate over 15 days for a 40 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Beta Blocker
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 4 h
- Common dose
- 40 mg
- Suggested maximum
- 320 mg/day
- Reference dose range
- 20–320 mg (single dose)
- Suggested cadence
- twice daily
- Validated against
- 40 mg oral — Cmax 0.045 mg/L at 1.5 h
Documented interactions
-
danger
25I-NBOMe + Propranolol (Inderal)
25I-NBOMe and Propranolol (Inderal) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
-
danger
2C-I (2,5-Dimethoxy-4-iodophenethylamine) + Propranolol (Inderal)
2C-I (2,5-Dimethoxy-4-iodophenethylamine) and Propranolol (Inderal) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
-
danger
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Propranolol (Inderal)
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) and Propranolol (Inderal) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
-
danger
4-AcO-DMT (Psilacetin) + Propranolol (Inderal)
4-AcO-DMT (Psilacetin) and Propranolol (Inderal) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
-
danger
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) + Propranolol (Inderal)
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) and Propranolol (Inderal) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…
-
danger
6-APB (Benzofury / 6-(2-aminopropyl)benzofuran) + Propranolol (Inderal)
6-APB (Benzofury / 6-(2-aminopropyl)benzofuran) and Propranolol (Inderal) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…
Serum checks 124 modeled interaction pairings for propranolol (inderal) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.
Research behind this entry
-
Propranolol in the treatment of essential tremor
Early double-blind crossover trial demonstrating propranolol significantly reduces essential tremor amplitude compared to placebo, establishing beta-blockers as first-line tremor therapy.
-
Effect of propranolol in the treatment of performance anxiety in musicians
Double-blind placebo-controlled study showing propranolol improved musical performance quality and reduced stage fright symptoms in professional musicians.
-
Pharmacokinetics of propranolol: a review
Comprehensive pharmacokinetic review establishing propranolol half-life of 3-6 hours, 25% oral bioavailability due to extensive hepatic first-pass metabolism, and wide interindividual variability.
3 published studies referenced in the app, each with a plain-language summary.