Home › Compound Library › 25I-NBOMe

25I-NBOMe

Psychedelicoral · inferred

EXTREMELY DANGEROUS synthetic phenethylamine and potent full 5-HT2A agonist. WARNING: Multiple deaths reported at doses of 2+ tabs. NO established safe dose. Often sold as fake LSD on blotter paper (distinguishable by bitter/metallic taste and oral numbness — LSD is tasteless). Effects last ~4-6 hours. Causes severe vasoconstriction, seizures, hyperthermia, rhabdomyolysis, and multi-organ failure. At least 21 deaths in Europe and 19+ in the US as of 2015. Unlike LSD, has significant physical toxicity and a narrow margin between active and lethal dose.

Projected serum levels — 1 tabs (≈ 1 mg), as needed (shown daily)

25I-NBOMe
25I-NBOMe modeled serum levels, 1 tabs (≈ 1 mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1 tabs (≈ 1 mg) as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 0.27 mg, trough ≈ 0.012 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Psychedelic
Route modeled
Oral
Model confidence
inferred
Half-life
5.1 h
Common dose
1 tabs (≈ 1 mg)
Reference dose range
0.50–2 tabs (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • danger
    1P-LSD (1-Propionyl-LSD) + 25I-NBOMe Serotonin risk

    1P-LSD (1-Propionyl-LSD) and 25I-NBOMe both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + 25I-NBOMe Serotonin risk

    25I-NBOMe and 2C-B (4-Bromo-2,5-dimethoxyphenethylamine) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    3-MeO-PCP (3-Methoxyphencyclidine) + 25I-NBOMe Serotonin risk

    25I-NBOMe and 3-MeO-PCP (3-Methoxyphencyclidine) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    4-AcO-DMT (Psilacetin) + 25I-NBOMe Serotonin risk

    25I-NBOMe and 4-AcO-DMT (Psilacetin) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    5-HTP (5-Hydroxytryptophan) + 25I-NBOMe Serotonin risk

    25I-NBOMe and 5-HTP (5-Hydroxytryptophan) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) + 25I-NBOMe Serotonin risk

    25I-NBOMe and 5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

Serum checks 182 modeled interaction pairings for 25i-nbome across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Toxicities associated with NBOMe ingestion, a novel class of potent hallucinogens: A review of the literature Suzuki J et al. · Psychosomatics, 2015 DOI

    Review of 20 NBOMe intoxication cases documenting 15% fatality rate, 40% ICU admission rate, and common presentations of agitation, tachycardia, hypertension, and seizures.

  2. Neurotoxicological profile of the hallucinogenic compound 25I-NBOMe Miner NB et al. · Scientific Reports, 2022 DOI

    Preclinical study demonstrating 25I-NBOMe neurotoxic and cardiotoxic activity, blood-brain barrier penetration within 15 minutes, and brain tissue accumulation with repeated dosing.

  3. Fatal Intoxications with 25B-NBOMe and 25I-NBOMe in Indiana During 2014 Poklis JL et al. · Journal of Analytical Toxicology, 2015 DOI

    Forensic toxicology report of fatal 25I-NBOMe and 25B-NBOMe cases with postmortem tissue concentrations, demonstrating lethal outcomes even at doses indistinguishable from typical recreational use.

3 published studies referenced in the app, each with a plain-language summary.