Home › Compound Library › Lisinopril

Lisinopril

ACE Inhibitorprescriptionoral · inferred

ACE inhibitor for hypertension and heart failure. Not metabolized; excreted unchanged in urine. Effective half-life ~12 hours supports once-daily dosing.

Projected serum levels — 10 mg, once daily

Lisinopril
Lisinopril modeled serum levels, 10 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 2 days. 0 0.63 1.3 1.9 2.5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 2
Lisinopril modeled serum levels with a loading dose of 14.1 mg, then 10 mg once daily The first dose is larger so levels approach steady state faster. 0 0.63 1.3 1.9 2.5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 10 mg once daily (oral).

Loading schedule: 14.1 mg on day 1, then 10 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~2 days: peak ≈ 2.5 mg, trough ≈ 0.99 mg body load. Population-based estimate over 15 days for a 10 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
ACE Inhibitor
Route modeled
Oral
Model confidence
inferred
Half-life
12 h
Common dose
10 mg
Suggested maximum
40 mg/day
Reference dose range
5–40 mg (single dose)
Suggested cadence
once daily
Validated against
20 mg oral — Cmax 0.070 mg/L at 6 h

Documented interactions

  • warning
    Combined OC (Drospirenone / Ethinyl Estradiol) + Lisinopril Potentiation

    Both drospirenone and ACE inhibitors raise potassium. Combined use increases hyperkalemia risk.

  • warning
    Potassium (Citrate) + Lisinopril Potentiation

    ACE inhibitors reduce potassium excretion. Supplementing potassium on top risks dangerous hyperkalemia.

  • warning
    Spironolactone (Anti-Androgen) + Lisinopril Potentiation

    Both spironolactone and ACE inhibitors raise potassium. Combined use requires potassium monitoring.

  • watch
    Enalapril (Vasotec) + Lisinopril Stacked effects

    Enalapril (Vasotec) and Lisinopril both push the ace in the same direction.

  • watch
    Enalaprilat + Lisinopril Stacked effects

    Enalaprilat and Lisinopril both push the ace in the same direction.

  • watch
    Garlic Extract (Allium sativum) + Lisinopril Stacked effects

    Garlic Extract (Allium sativum) and Lisinopril both push the ace in the same direction.

Serum checks 8 modeled interaction pairings for lisinopril across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients (HOPE study) Yusuf S et al. · New England Journal of Medicine, 2000 DOI

    Landmark HOPE trial demonstrated ACE inhibitors reduce cardiovascular events by 22%, stroke by 32%, and cardiovascular death by 26% in high-risk patients.

  2. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic (ALLHAT) ALLHAT Officers and Coordinators · JAMA, 2002 DOI

    Largest hypertension trial ever (42,418 patients) found lisinopril was as effective as chlorthalidone for preventing fatal coronary heart disease, with similar outcomes across groups.

  3. Assessment of Treatment with Lisinopril and Survival (ATLAS): a randomised trial of high vs low doses in patients with heart failure Packer M et al. · Circulation, 1999 DOI

    RCT of 3,164 heart failure patients found high-dose lisinopril (32.5-35 mg) reduced hospitalizations by 12% compared to low-dose (2.5-5 mg), supporting higher dose targets.

3 published studies referenced in the app, each with a plain-language summary.