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Spironolactone (Anti-Androgen)

HRTprescriptionoral · inferred

Potassium-sparing diuretic with potent anti-androgen effects. Blocks androgen receptors and inhibits testosterone synthesis. Parent drug has very short t1/2 (~1.4h) but active metabolite canrenone persists ~16h. Used in feminizing HRT, PCOS, acne, and hirsutism.

Projected serum levels — 100 mg, once daily

Spironolactone (Anti-Androgen)
Spironolactone (Anti-Androgen) modeled serum levels, 100 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 12.5 25 37.5 50 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 100 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 27.0 mg, trough ≈ 0.006 mg body load. Population-based estimate over 15 days for a 100 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
HRT
Route modeled
Oral
Model confidence
inferred
Half-life
1.4 h
Common dose
100 mg
Suggested maximum
300 mg/day
Reference dose range
50–300 mg (single dose)
Suggested cadence
once daily
Validated against
100 mg oral — Cmax 0.40 mg/L at 2.6 h

Documented interactions

  • danger
    Candesartan + Spironolactone (Anti-Androgen) CYP inhibition

    Spironolactone (Anti-Androgen) reversible_inhibitor of CYP2C9 predicted to change Candesartan AUC by ~3.33x

  • danger
    Carbamazepine (Tegretol) + Spironolactone (Anti-Androgen) CYP induction

    Carbamazepine (Tegretol) inducer of CYP3A4 predicted to change Spironolactone (Anti-Androgen) AUC by ~0.31x

  • danger
    Celecoxib (Celebrex) + Spironolactone (Anti-Androgen) CYP inhibition

    Spironolactone (Anti-Androgen) reversible_inhibitor of CYP2C9 predicted to change Celecoxib (Celebrex) AUC by ~2.97x

  • danger
    Clarithromycin (Biaxin) + Spironolactone (Anti-Androgen) CYP inhibition

    Clarithromycin (Biaxin) mechanism_based of CYP3A4 predicted to change Spironolactone (Anti-Androgen) AUC by ~2.00x

  • danger
    Combined OC (Drospirenone / Ethinyl Estradiol) + Spironolactone (Anti-Androgen) Stacked effects

    Combined OC (Drospirenone / Ethinyl Estradiol) and Spironolactone (Anti-Androgen) both push the androgen receptor, mineralocorticoid receptor, and progesterone receptor in the same direction.

  • danger
    Diltiazem + Spironolactone (Anti-Androgen) CYP inhibition

    Diltiazem mechanism_based of CYP3A4 predicted to change Spironolactone (Anti-Androgen) AUC by ~2.00x

Serum checks 116 modeled interaction pairings for spironolactone (anti-androgen) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Spironolactone and Endocrine Dysfunction Loriaux DL et al. · Annals of Internal Medicine, 1976 DOI

    Foundational study establishing spironolactone anti-androgenic mechanism: blocks testosterone synthesis, competes for androgen receptor, and increases SHBG.

  2. Spironolactone in Dermatology Kim GK, Del Rosso JQ · Journal of Clinical and Aesthetic Dermatology, 2012 DOI

    Review of spironolactone dermatologic uses covering acne, hirsutism, and androgenic alopecia at 100-200 mg/day with monitoring for hyperkalemia.

  3. Use of Spironolactone in Transgender Women Angus LM et al. · Transgender Health, 2019 DOI

    Retrospective study of spironolactone in feminizing HRT showing effective testosterone suppression at 100-300 mg/day with manageable potassium elevation.

3 published studies referenced in the app, each with a plain-language summary.