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Potassium (Citrate)

Mineraloral · inferred

Critical electrolyte for heart rhythm, muscle contractions, and fluid balance. Most adults do not get enough from diet alone.

Projected serum levels — 99 mg, once daily

Potassium (Citrate)
Potassium (Citrate) modeled serum levels, 99 mg once daily over 106 days Population-based pharmacokinetic estimate. Steady state reached after approximately 38 days. 0 500 1k 1.5k 2k Day 0 Day 27 Day 53 Day 80 Day 106 Time on a regular schedule ≈ steady state · day 38
Potassium (Citrate) modeled serum levels with a loading dose of 297 mg, then 99 mg once daily The first dose is larger so levels approach steady state faster. 0 500 1k 1.5k 2k Day 0 Day 27 Day 53 Day 80 Day 106 Time on a regular schedule

Maintenance schedule: 99 mg once daily (oral).

Loading schedule: 297 mg on day 1, then 99 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~38 days: peak ≈ 1.8k mg, trough ≈ 1.7k mg body load. Population-based estimate over 106 days for a 99 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Mineral
Route modeled
Oral
Model confidence
inferred
Half-life
14 days
Common dose
99 mg
Suggested maximum
500 mg/day
Reference dose range
49.5–500 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    Spironolactone (Anti-Androgen) + Potassium (Citrate) Contraindicated

    Spironolactone is potassium-sparing. Combined with potassium supplements risks dangerous hyperkalemia.

  • warning
    Combined OC (Drospirenone / Ethinyl Estradiol) + Potassium (Citrate) Potentiation

    Drospirenone has anti-mineralocorticoid activity (potassium-sparing). Combining with potassium supplements can cause hyperkalemia.

  • warning
    Lisinopril + Potassium (Citrate) Potentiation

    ACE inhibitors reduce potassium excretion. Supplementing potassium on top risks dangerous hyperkalemia.

Serum checks 3 modeled interaction pairings for potassium (citrate) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses Aburto NJ et al. · BMJ, 2013 DOI

    WHO-commissioned meta-analysis found increased potassium intake reduced blood pressure in hypertensive adults and was associated with a 24% lower risk of stroke.

  2. Potassium intake, stroke, and cardiovascular disease: a meta-analysis of prospective studies D'Elia L et al. · Journal of the American College of Cardiology, 2011 DOI

    Meta-analysis of 11 prospective studies found that each 1.64 g/day increase in potassium intake was associated with a 21% reduced risk of stroke.

  3. Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women Moseley KF et al. · Journal of Bone and Mineral Research, 2013 DOI

    Study showed potassium citrate supplementation improved calcium balance and reduced urinary calcium loss, supporting bone health in older adults.

3 published studies referenced in the app, each with a plain-language summary.