Home › Compound Library › Enalapril (Vasotec)

Enalapril (Vasotec)

ACE Inhibitorprescriptionoral · inferred

Prodrug ACE inhibitor hydrolyzed in liver to active enalaprilat. Inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion. Used for hypertension, heart failure, asymptomatic LV dysfunction, and diabetic nephropathy. The PK values represent the active enalaprilat profile. Renally eliminated — dose-adjust in renal impairment. Class effects: dry cough (5-20%), hyperkalemia, rare angioedema.

Projected serum levels — 10 mg, twice daily

Enalapril (Vasotec) (precursor)Enalaprilat
Enalapril (Vasotec) modeled serum levels, 10 mg twice daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 1.3 2.5 3.8 5 Day 0 Day 4 Day 7 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 10 mg twice daily (oral).

Modeled steady state after ~1 days: peak ≈ 2.6 mg, trough ≈ 0.005 mg body load. Population-based estimate over 15 days for a 10 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
ACE Inhibitor
Route modeled
Oral
Model confidence
inferred
Half-life
2 h
Common dose
10 mg
Suggested maximum
40 mg/day
Reference dose range
5–40 mg (single dose)
Suggested cadence
twice daily
Validated against
10 mg oral — Cmax 0.080 mg/L at 1 h

Documented interactions

  • watch
    Enalaprilat + Enalapril (Vasotec) Stacked effects

    Enalapril (Vasotec) and Enalaprilat both push the ace in the same direction.

  • watch
    Garlic Extract (Allium sativum) + Enalapril (Vasotec) Stacked effects

    Enalapril (Vasotec) and Garlic Extract (Allium sativum) both push the ace in the same direction.

  • watch
    Lisinopril + Enalapril (Vasotec) Stacked effects

    Enalapril (Vasotec) and Lisinopril both push the ace in the same direction.

  • watch
    Ramipril + Enalapril (Vasotec) Stacked effects

    Enalapril (Vasotec) and Ramipril both push the ace in the same direction.

Serum checks 5 modeled interaction pairings for enalapril (vasotec) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced ejection fractions (SOLVD Prevention trial) SOLVD Investigators · New England Journal of Medicine, 1992 DOI

    Landmark prevention trial (4228 patients) demonstrating enalapril reduced heart failure development by 37% and HF hospitalization by 36% in patients with asymptomatic LV dysfunction, establishing early ACE inhibitor use.

  2. Effects of enalapril on mortality in severe congestive heart failure (CONSENSUS trial) CONSENSUS Trial Study Group · New England Journal of Medicine, 1987 DOI

    Historic first trial showing ACE inhibitor mortality benefit: enalapril reduced 6-month mortality by 40% in NYHA class IV heart failure, fundamentally changing heart failure management.

2 published studies referenced in the app, each with a plain-language summary.