Caffeine
Adenosine receptor antagonist that increases alertness and focus. Half-life varies significantly with genetics (CYP1A2).
Projected serum levels — 100 mg, once daily
Maintenance schedule: 100 mg once daily (oral).
Modeled steady state after ~1 days: peak ≈ 60.7 mg, trough ≈ 0.010 mg body load. Population-based estimate over 15 days for a 100 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Stimulant
- Route modeled
- Oral
- Model confidence
- predicted
- Half-life
- 5 h
- Common dose
- 100 mg
- Suggested maximum
- 400 mg/day
- Reference dose range
- 30–400 mg (single dose)
- Suggested cadence
- once daily
- Validated against
- 200 mg oral — Cmax 4.5 mg/L at 1 h
Documented interactions
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danger
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Caffeine
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) and Caffeine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status). High-dose…
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danger
4-AcO-DMT (Psilacetin) + Caffeine
4-AcO-DMT (Psilacetin) and Caffeine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status). High-dose caffeine amplifies…
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danger
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) + Caffeine
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) and Caffeine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status). High-dose…
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danger
6-APB (Benzofury / 6-(2-aminopropyl)benzofuran) + Caffeine
6-APB (Benzofury / 6-(2-aminopropyl)benzofuran) and Caffeine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).…
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danger
Apigenin + Caffeine
Apigenin reversible_inhibitor of CYP1A2 predicted to change Caffeine AUC by ~2.99x
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danger
Aripiprazole (Abilify) + Caffeine
Aripiprazole (Abilify) and Caffeine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status). High-dose caffeine amplifies…
Serum checks 100 modeled interaction pairings for caffeine across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.
Research behind this entry
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Effects of caffeine on cognitive performance, mood, and alertness in sleep-deprived humans
Comprehensive review confirming caffeine improves cognitive performance, reaction time, and mood during both rested and sleep-deprived states, with peak effects at 200-300 mg.
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Caffeine and sports performance
ISSN position stand concluding caffeine is effective for enhancing sport performance when consumed in doses of 3-6 mg/kg body mass.
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Habitual coffee consumption and risk of cardiovascular disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta-analysis of 36 studies found moderate coffee consumption (3-5 cups/day) was associated with lower cardiovascular disease risk, with a nonlinear dose-response relationship.
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Exercise and sport performance with low doses of caffeine
This narrative review found that doses below 3 mg/kg (roughly 200 mg) can improve vigilance, alertness, mood, cognition, and some exercise outcomes with fewer adverse effects than larger doses. It also emphasized…
5 published studies referenced in the app, each with a plain-language summary.