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Green Tea Extract (Camellia sinensis)

Herboral · inferred

Standardized green tea containing EGCG and polyphenols. Most preparations contain caffeine. Low bioavailability due to extensive gut metabolism.

Projected serum levels — 500 mg, once daily

Green Tea Extract (Camellia sinensis)
Green Tea Extract (Camellia sinensis) modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 2.5 5 7.5 10 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 500 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 9.3 mg, trough ≈ 0.016 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Herb
Route modeled
Oral
Model confidence
inferred
Half-life
1.7 h
Common dose
500 mg
Suggested maximum
800 mg/day
Reference dose range
250–800 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Green Tea Extract (Camellia sinensis) CYP inhibition

    Green Tea Extract (Camellia sinensis) reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Alfuzosin (Uroxatral) + Green Tea Extract (Camellia sinensis) CYP inhibition

    Green Tea Extract (Camellia sinensis) reversible_inhibitor of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~3.33x

  • danger
    Alprazolam (Xanax) + Green Tea Extract (Camellia sinensis) CYP inhibition

    Green Tea Extract (Camellia sinensis) reversible_inhibitor of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~3.33x

  • danger
    Amlodipine (Norvasc) + Green Tea Extract (Camellia sinensis) CYP inhibition

    Green Tea Extract (Camellia sinensis) reversible_inhibitor of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~3.33x

  • danger
    Anastrozole (Arimidex) + Green Tea Extract (Camellia sinensis) CYP inhibition

    Green Tea Extract (Camellia sinensis) reversible_inhibitor of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~2.68x

  • danger
    Astaxanthin + Green Tea Extract (Camellia sinensis) CYP inhibition

    Green Tea Extract (Camellia sinensis) reversible_inhibitor of CYP3A4 predicted to change Astaxanthin AUC by ~3.33x

Serum checks 253 modeled interaction pairings for green tea extract (camellia sinensis) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals Chow HH et al. · Clinical Cancer Research, 2003 DOI

    Pharmacokinetics of EGCG in healthy volunteers.

  2. Therapeutic Effects of Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis Henning SM et al. · International Journal of Molecular Sciences, 2022 DOI

    Comprehensive mechanisms and bioavailability review.

  3. Population nutrikinetics of green tea extract Stalmach A et al. · PLOS One, 2019 DOI

    Population pharmacokinetics showing high variability.

  4. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial Chen IJ et al. · Clinical Nutrition, 2016 DOI

    Twelve-week randomized trial of decaffeinated green tea extract providing 856.8 mg EGCG daily in women with central obesity. The treatment group lost about 1.1 kg and had within-group reductions in BMI and waist…

4 published studies referenced in the app, each with a plain-language summary.