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Bacopa Monnieri (Brahmi)

Herbal Nootropicoral · inferred

Traditional Ayurvedic herb rich in bacosides (triterpenoid saponins). Requires 4-6 weeks of daily use for full cognitive effects. Enhances serotonergic and cholinergic activity, with demonstrated effects on memory consolidation and free recall. Standardised extracts typically contain 50% bacosides.

Projected serum levels — 300 mg, once daily

Bacopa Monnieri (Brahmi)
Bacopa Monnieri (Brahmi) modeled serum levels, 300 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 5 10 15 20 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 300 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 10.7 mg, trough ≈ 0.32 mg body load. Population-based estimate over 15 days for a 300 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Herbal Nootropic
Route modeled
Oral
Model confidence
inferred
Half-life
4.1 h
Common dose
300 mg
Suggested maximum
600 mg/day
Reference dose range
150–600 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    25I-NBOMe + Bacopa Monnieri (Brahmi) Serotonin risk

    25I-NBOMe and Bacopa Monnieri (Brahmi) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    2C-I (2,5-Dimethoxy-4-iodophenethylamine) + Bacopa Monnieri (Brahmi) Serotonin risk

    2C-I (2,5-Dimethoxy-4-iodophenethylamine) and Bacopa Monnieri (Brahmi) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…

  • danger
    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Bacopa Monnieri (Brahmi) Serotonin risk

    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) and Bacopa Monnieri (Brahmi) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…

  • danger
    4-AcO-DMT (Psilacetin) + Bacopa Monnieri (Brahmi) Serotonin risk

    4-AcO-DMT (Psilacetin) and Bacopa Monnieri (Brahmi) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) + Bacopa Monnieri (Brahmi) Serotonin risk

    5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) and Bacopa Monnieri (Brahmi) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…

  • danger
    6-APB (Benzofury / 6-(2-aminopropyl)benzofuran) + Bacopa Monnieri (Brahmi) Serotonin risk

    6-APB (Benzofury / 6-(2-aminopropyl)benzofuran) and Bacopa Monnieri (Brahmi) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…

Serum checks 103 modeled interaction pairings for bacopa monnieri (brahmi) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract Kongkeaw C et al. · Journal of Ethnopharmacology, 2014 DOI

    Meta-analysis of RCTs with 12+ weeks standardised Bacopa extract concluded it has potential to improve cognition, particularly speed of attention.

  2. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials Pase MP et al. · Journal of Alternative and Complementary Medicine, 2012 DOI

    Systematic review of 6 RCTs (300-450 mg/day, 12 weeks) found Bacopa improved performance on 9 of 17 memory free recall tests with consistent evidence for memory enhancement.

  3. Effects of 12-week Bacopa monnieri consumption on attention, cognitive processing, working memory, and functions of both cholinergic and monoaminergic systems in healthy elderly volunteers Peth-Nui T et al. · Evidence-Based Complementary and Alternative Medicine, 2012 DOI

    RCT in 60 healthy elderly showed 300 mg/day Bacopa for 12 weeks improved attention, cognitive processing, and working memory while modulating cholinergic and monoaminergic systems.

  4. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B · Journal of alternative and complementary medicine (New York, N.Y.), 2008 DOI

    This citation reports a human clinical study involving Bacopa Monnieri (Brahmi). It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.