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Turmeric / Curcumin

Herboral · inferred

Potent anti-inflammatory compound. Bioavailability is enhanced with piperine (black pepper extract).

Projected serum levels — 500 mg, once daily

Turmeric / Curcumin
Turmeric / Curcumin modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 3 days. 0 1.3 2.5 3.8 5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 3
Turmeric / Curcumin modeled serum levels with a loading dose of 905 mg, then 500 mg once daily The first dose is larger so levels approach steady state faster. 0 1.3 2.5 3.8 5 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 500 mg once daily (oral).

Loading schedule: 905 mg on day 1, then 500 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~3 days: peak ≈ 3.7 mg, trough ≈ 2.0 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Herb
Route modeled
Oral
Model confidence
inferred
Half-life
20 h
Common dose
500 mg
Suggested maximum
2k mg/day
Reference dose range
250–2k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Turmeric / Curcumin CYP inhibition

    Turmeric / Curcumin reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Alfuzosin (Uroxatral) + Turmeric / Curcumin CYP inhibition

    Turmeric / Curcumin reversible_inhibitor of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~3.33x

  • danger
    Alprazolam (Xanax) + Turmeric / Curcumin CYP inhibition

    Turmeric / Curcumin reversible_inhibitor of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~3.33x

  • danger
    Amlodipine (Norvasc) + Turmeric / Curcumin CYP inhibition

    Turmeric / Curcumin reversible_inhibitor of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~3.33x

  • danger
    Anastrozole (Arimidex) + Turmeric / Curcumin CYP inhibition

    Turmeric / Curcumin reversible_inhibitor of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~2.68x

  • danger
    Astaxanthin + Turmeric / Curcumin CYP inhibition

    Turmeric / Curcumin reversible_inhibitor of CYP3A4 predicted to change Astaxanthin AUC by ~3.33x

Serum checks 313 modeled interaction pairings for turmeric / curcumin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Efficacy of curcumin in the management of chronic anterior uveitis Lal B et al. · Phytotherapy Research, 1999 DOI

    Clinical study found curcumin was as effective as corticosteroid therapy for chronic inflammatory eye disease, demonstrating potent anti-inflammatory properties.

  2. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial Lopresti AL et al. · Journal of Affective Disorders, 2014 DOI

    RCT found curcumin (1000 mg/day) was as effective as fluoxetine for treating major depression, with combination therapy showing the highest response rate.

  3. Curcumin: a review of its effects on human health Hewlings SJ et al. · Foods, 2017 DOI

    Comprehensive review of curcumin benefits including anti-inflammatory, antioxidant, and anticancer properties, noting bioavailability challenges and enhancement strategies.

3 published studies referenced in the app, each with a plain-language summary.