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Black Seed Oil (Nigella sativa / Thymoquinone)

Herboral · inferred

Cold-pressed oil from Nigella sativa seeds, with thymoquinone as the primary active compound. Anti-inflammatory, antioxidant, and immunomodulatory. Traditional medicine use spanning 2000+ years. Supports blood sugar management and respiratory health.

Projected serum levels — 1k mg, once daily

Black Seed Oil (Nigella sativa / Thymoquinone)
Black Seed Oil (Nigella sativa / Thymoquinone) modeled serum levels, 1k mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 12.5 25 37.5 50 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1k mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 33.4 mg, trough ≈ 0.002 mg body load. Population-based estimate over 15 days for a 1k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Herb
Route modeled
Oral
Model confidence
inferred
Half-life
1.1 h
Common dose
1k mg
Suggested maximum
3k mg/day
Reference dose range
500–3k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Black Seed Oil (Nigella sativa / Thymoquinone) CYP inhibition

    Black Seed Oil (Nigella sativa / Thymoquinone) reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Alfuzosin (Uroxatral) + Black Seed Oil (Nigella sativa / Thymoquinone) CYP inhibition

    Black Seed Oil (Nigella sativa / Thymoquinone) reversible_inhibitor of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~3.33x

  • danger
    Alprazolam (Xanax) + Black Seed Oil (Nigella sativa / Thymoquinone) CYP inhibition

    Black Seed Oil (Nigella sativa / Thymoquinone) reversible_inhibitor of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~3.33x

  • danger
    Amlodipine (Norvasc) + Black Seed Oil (Nigella sativa / Thymoquinone) CYP inhibition

    Black Seed Oil (Nigella sativa / Thymoquinone) reversible_inhibitor of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~3.33x

  • danger
    Anastrozole (Arimidex) + Black Seed Oil (Nigella sativa / Thymoquinone) CYP inhibition

    Black Seed Oil (Nigella sativa / Thymoquinone) reversible_inhibitor of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~2.68x

  • danger
    Astaxanthin + Black Seed Oil (Nigella sativa / Thymoquinone) CYP inhibition

    Black Seed Oil (Nigella sativa / Thymoquinone) reversible_inhibitor of CYP3A4 predicted to change Astaxanthin AUC by ~3.33x

Serum checks 355 modeled interaction pairings for black seed oil (nigella sativa / thymoquinone) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. A Review on Therapeutic Potential of Nigella sativa: A Miracle Herb Ahmad A et al. · Asian Pacific Journal of Tropical Biomedicine, 2013 DOI

    Comprehensive review of Nigella sativa pharmacology covering anti-diabetic, anticancer, immunomodulatory, anti-inflammatory, and hepatoprotective effects.

  2. Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure Salehi B et al. · Drug Design, Development and Therapy, 2021 DOI

    Reviewed thymoquinone pharmacokinetics including rapid oral absorption, hepatic metabolism, and broad-spectrum anti-inflammatory and immunomodulatory mechanisms.

  3. Effect of Nigella Sativa Supplementation on Blood Glucose, Lipid Profile and Body Composition: A Systematic Review and Meta-Analysis Daryabeygi-Khotbehsara R et al. · Journal of Functional Foods, 2017 DOI

    Meta-analysis of 17 RCTs showing significant reductions in fasting glucose, HbA1c, total cholesterol, and LDL with Nigella sativa supplementation.

  4. Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety Hannan MA et al. · Nutrients, 2021 DOI

    Broad review of black cumin seed and oil covering phytochemical composition, thymoquinone-centered mechanisms, preclinical findings, available human studies, and safety. It highlights substantial formulation variability…

5 published studies referenced in the app, each with a plain-language summary.