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SS-31 (Elamipretide)

Peptidesubcutaneous · inferred

Mitochondria-targeted tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that concentrates more than 1000-fold in the inner mitochondrial membrane. Binds cardiolipin to stabilize cristae structure and optimize electron transport chain. Half-life ~4 hours SC. Cleared renally. Investigated for Barth syndrome, primary mitochondrial myopathy, and age-related mitochondrial dysfunction.

Projected serum levels — 40 mg, once daily

SS-31 (Elamipretide)
SS-31 (Elamipretide) modeled serum levels, 40 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 12.5 25 37.5 50 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 40 mg once daily (subcutaneous).

Modeled steady state after ~1 days: peak ≈ 31.5 mg, trough ≈ 0.77 mg body load. Population-based estimate over 15 days for a 40 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
Subcutaneous
Model confidence
inferred
Half-life
4.1 h
Common dose
40 mg
Suggested maximum
40 mg/day
Reference dose range
20–40 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • watch
    Copper (Bisglycinate) + SS-31 (Elamipretide) Stacked effects

    Copper (Bisglycinate) and SS-31 (Elamipretide) both push the mitochondrial electron transport in the same direction.

  • watch
    CoQ10 (Ubiquinol) + SS-31 (Elamipretide) Stacked effects

    CoQ10 (Ubiquinol) and SS-31 (Elamipretide) both push the mitochondrial electron transport in the same direction.

  • watch
    2,4-Dinitrophenol (DNP) + SS-31 (Elamipretide) Stacked effects

    2,4-Dinitrophenol (DNP) and SS-31 (Elamipretide) both push the mitochondrial electron transport in the same direction.

  • watch
    Riboflavin (Vitamin B2) + SS-31 (Elamipretide) Stacked effects

    Riboflavin (Vitamin B2) and SS-31 (Elamipretide) both push the mitochondrial electron transport in the same direction.

Serum checks 4 modeled interaction pairings for ss-31 (elamipretide) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy Karaa A et al. · Neurology, 2018 DOI

    Phase 1/2 dose-escalation trial showing elamipretide was well-tolerated in patients with primary mitochondrial myopathy and demonstrated dose-dependent improvements in the 6-minute walk test.

  2. Mitochondrial protein interaction landscape of SS-31 Chavez JD et al. · Proceedings of the National Academy of Sciences, 2020 DOI

    Cross-linking mass spectrometry study revealing SS-31 directly interacts with multiple mitochondrial proteins and remodels the protein interaction landscape of the inner mitochondrial membrane.

  3. SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease Zhao W et al. · Oxidative Medicine and Cellular Longevity, 2022 DOI

    Review of SS-31 mechanisms in kidney disease showing it restores mitochondrial function, reduces oxidative stress, and attenuates renal fibrosis through cardiolipin-dependent cristae stabilization.

3 published studies referenced in the app, each with a plain-language summary.