Home › Compound Library › Riboflavin (Vitamin B2)

Riboflavin (Vitamin B2)

Vitaminoral · inferred

Water-soluble vitamin essential for energy production as a precursor to FAD and FMN coenzymes. High doses used for migraine prevention.

Projected serum levels — 25 mg, once daily

Riboflavin (Vitamin B2)
Riboflavin (Vitamin B2) modeled serum levels, 25 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 2.5 5 7.5 10 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 25 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 6.5 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 25 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Vitamin
Route modeled
Oral
Model confidence
inferred
Half-life
1.5 h
Common dose
25 mg
Suggested maximum
400 mg/day
Reference dose range
12.5–400 mg (single dose)
Suggested cadence
once daily
Validated against
25 mg oral — Cmax 0.38 mg/L at 1.5 h

Documented interactions

  • watch
    Copper (Bisglycinate) + Riboflavin (Vitamin B2) Stacked effects

    Copper (Bisglycinate) and Riboflavin (Vitamin B2) both push the mitochondrial electron transport in the same direction.

  • watch
    CoQ10 (Ubiquinol) + Riboflavin (Vitamin B2) Stacked effects

    CoQ10 (Ubiquinol) and Riboflavin (Vitamin B2) both push the mitochondrial electron transport in the same direction.

  • watch
    2,4-Dinitrophenol (DNP) + Riboflavin (Vitamin B2) Stacked effects

    2,4-Dinitrophenol (DNP) and Riboflavin (Vitamin B2) both push the mitochondrial electron transport in the same direction.

  • watch
    Methylene Blue + Riboflavin (Vitamin B2) Stacked effects

    Methylene Blue and Riboflavin (Vitamin B2) both push the mitochondrial electron transport in the same direction.

  • watch
    MOTS-c + Riboflavin (Vitamin B2) Stacked effects

    MOTS-c and Riboflavin (Vitamin B2) both push the mitochondrial electron transport in the same direction.

  • watch
    Shilajit (Purified Fulvic Acid Complex) + Riboflavin (Vitamin B2) Stacked effects

    Riboflavin (Vitamin B2) and Shilajit (Purified Fulvic Acid Complex) both push the mitochondrial electron transport in the same direction.

Serum checks 7 modeled interaction pairings for riboflavin (vitamin b2) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial Schoenen J et al. · Neurology, 1998 DOI

    Landmark RCT found 400 mg/day riboflavin reduced migraine frequency by 50% in 59% of patients compared to 15% for placebo, establishing it as an effective migraine preventive.

  2. Riboflavin has neuroprotective potential: focus on Parkinson's disease and migraine Marashly ET et al. · Frontiers in Neurology, 2017 DOI

    Review of riboflavin neuroprotective mechanisms including mitochondrial energy production, antioxidant properties, and glutamate metabolism relevant to migraine and neurodegenerative diseases.

  3. Vitamins and migraine: could we, should we? Namazi N et al. · Headache, 2015 DOI

    Review supporting riboflavin 400 mg/day as a safe, well-tolerated migraine prophylactic with evidence comparable to some prescription medications.

3 published studies referenced in the app, each with a plain-language summary.