Home › Compound Library › CoQ10 (Ubiquinol)

CoQ10 (Ubiquinol)

Antioxidantoral · inferred

Critical for cellular energy production (mitochondrial function). Levels decline with age and statin use.

Projected serum levels — 100 mg, once daily

CoQ10 (Ubiquinol)
CoQ10 (Ubiquinol) modeled serum levels, 100 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 4 days. 0 5 10 15 20 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 4
CoQ10 (Ubiquinol) modeled serum levels with a loading dose of 253 mg, then 100 mg once daily The first dose is larger so levels approach steady state faster. 0 5 10 15 20 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 100 mg once daily (oral).

Loading schedule: 253 mg on day 1, then 100 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~4 days: peak ≈ 11.2 mg, trough ≈ 7.5 mg body load. Population-based estimate over 15 days for a 100 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Antioxidant
Route modeled
Oral
Model confidence
inferred
Half-life
33 h
Common dose
100 mg
Suggested maximum
400 mg/day
Reference dose range
50–400 mg (single dose)
Suggested cadence
once daily
Validated against
200 mg oral — Cmax 1.3 mg/L at 6 h

Documented interactions

  • danger
    Levothyroxine (Synthroid) + CoQ10 (Ubiquinol) Protein binding

    CoQ10 (Ubiquinol) may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration…

  • danger
    Tacrolimus (Prograf) + CoQ10 (Ubiquinol) Protein binding

    CoQ10 (Ubiquinol) may displace Tacrolimus (Prograf) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration…

  • danger
    Warfarin (Coumadin) + CoQ10 (Ubiquinol) Protein binding

    CoQ10 (Ubiquinol) may displace Warfarin (Coumadin) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration changes…

  • warning
    Apigenin + CoQ10 (Ubiquinol) Protein binding

    Apigenin may displace CoQ10 (Ubiquinol) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Aripiprazole (Abilify) + CoQ10 (Ubiquinol) Protein binding

    Aripiprazole (Abilify) may displace CoQ10 (Ubiquinol) from plasma protein binding sites, transiently raising free drug concentration.

  • warning
    Armour Thyroid (Desiccated Thyroid Extract) + CoQ10 (Ubiquinol) Protein binding

    CoQ10 (Ubiquinol) may displace Armour Thyroid (Desiccated Thyroid Extract) from plasma protein binding sites, transiently raising free drug concentration.

Serum checks 146 modeled interaction pairings for coq10 (ubiquinol) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO Mortensen SA et al. · JACC: Heart Failure, 2014 DOI

    Landmark multicenter RCT found CoQ10 supplementation (300 mg/day) reduced cardiovascular mortality by 43% and all-cause mortality by 42% in heart failure patients over 2 years.

  2. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease Lee BJ et al. · Nutrition, 2012 DOI

    RCT showed CoQ10 supplementation (300 mg/day for 12 weeks) significantly reduced oxidative stress markers and increased antioxidant enzyme activity in coronary artery disease patients.

  3. Statin-associated myopathy with normal creatine kinase levels Caso G et al. · Annals of Internal Medicine, 2007 DOI

    Study demonstrated that statins deplete CoQ10 in muscle tissue, contributing to statin myopathy, and that CoQ10 supplementation may alleviate statin-related muscle symptoms.

3 published studies referenced in the app, each with a plain-language summary.