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MOTS-c

Peptidesubcutaneous · inferred

Mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA. 16-amino-acid peptide that regulates metabolic homeostasis by activating AMPK and promoting glucose uptake. Exercise-induced MOTS-c levels return to baseline within 4 hours. Acts as an exercise mimetic with insulin-sensitizing effects.

Projected serum levels — 5 mg, twice weekly

MOTS-c
MOTS-c modeled serum levels, 5 mg twice weekly over 18 days Population-based pharmacokinetic estimate. Steady state reached after approximately 7 days. 0 0.50 1 1.5 2 Day 0 Day 4 Day 9 Day 13 Day 18 Time on a regular schedule ≈ steady state · day 7

Maintenance schedule: 5 mg twice weekly (subcutaneous).

Modeled steady state after ~7 days: peak ≈ 1.3 mg, trough ≈ 0 mg body load. Population-based estimate over 18 days for a 5 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
Subcutaneous
Model confidence
inferred
Half-life
58 min
Common dose
5 mg
Suggested maximum
10 mg/day
Reference dose range
2.5–10 mg (single dose)
Suggested cadence
twice weekly

Documented interactions

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    Berberine + MOTS-c Stacked effects

    Berberine and MOTS-c both push the ampk in the same direction.

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    Copper (Bisglycinate) + MOTS-c Stacked effects

    Copper (Bisglycinate) and MOTS-c both push the mitochondrial electron transport in the same direction.

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    CoQ10 (Ubiquinol) + MOTS-c Stacked effects

    CoQ10 (Ubiquinol) and MOTS-c both push the mitochondrial electron transport in the same direction.

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    2,4-Dinitrophenol (DNP) + MOTS-c Stacked effects

    2,4-Dinitrophenol (DNP) and MOTS-c both push the mitochondrial electron transport in the same direction.

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    Panax Ginseng (Asian Ginseng) + MOTS-c Stacked effects

    Panax Ginseng (Asian Ginseng) and MOTS-c both push the ampk in the same direction.

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    Metformin + MOTS-c Stacked effects

    Metformin and MOTS-c both push the ampk in the same direction.

Serum checks 9 modeled interaction pairings for mots-c across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. The Mitochondrial-Derived Peptide MOTS-c: A Player in Exceptional Longevity? Zempo H et al. · Aging Cell, 2021 DOI

    Identified MOTS-c variant m.1382A>C as significantly associated with exceptional longevity in Japanese centenarians, suggesting MOTS-c plays a role in human aging and lifespan.

  2. MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis Reynolds JC et al. · Nature Communications, 2021 DOI

    Demonstrated MOTS-c is induced by exercise, translocates to the nucleus to regulate adaptive gene expression, and exogenous MOTS-c treatment improved physical performance in aged mice.

  3. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation Mohtashami Z et al. · Journal of Cellular and Molecular Medicine, 2022 DOI

    Comprehensive review of MOTS-c biology covering its metabolic effects via AMPK activation, insulin-sensitizing properties, anti-inflammatory actions, and potential therapeutic applications.

  4. MOTS-c modulates skeletal muscle function by directly binding and activating CK2. Kumagai H, Kim SJ, Miller B, Zempo H, Tanisawa K, Natsume T, Lee SH, Wan J, Leelaprachakul N, Kumagai ME, Ramirez R, Mehta HH, Cao K, Oh TJ, Wohlschlegel JA, Sha J, Nishida Y, Fuku N, Dobashi S, Miyamoto-Mikami E, Takaragawa M, Fuku M, Yoshihara T, Naito H, Kawakami R, Torii S, Midorikawa T, Oka K, Hara M, Iwasaka C, Yamada Y, Higaki Y, Tanaka K, Yen K, Cohen P · iScience, 2024 DOI

    This citation reports a laboratory or cell study involving MOTS-c. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.