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Melatonin

Hormoneoral · inferred

Hormone that regulates the sleep-wake cycle. Lower doses (0.3-0.5 mg) are often more effective than higher doses.

Projected serum levels — 0.50 mg, once daily

Melatonin
Melatonin modeled serum levels, 0.50 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 0.50 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 0.043 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 0.50 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Hormone
Route modeled
Oral
Model confidence
inferred
Half-life
42 min
Common dose
0.50 mg
Suggested maximum
10 mg/day
Reference dose range
0.25–10 mg (single dose)
Suggested cadence
once daily
Validated against
3 mg oral — Cmax 0.007 mg/L at 0.50 h

Documented interactions

  • danger
    Apigenin + Melatonin CYP inhibition

    Apigenin reversible_inhibitor of CYP1A2 predicted to change Melatonin AUC by ~2.97x

  • danger
    Ciprofloxacin (Cipro) + Melatonin CYP inhibition

    Ciprofloxacin (Cipro) reversible_inhibitor of CYP1A2 predicted to change Melatonin AUC by ~2.97x

  • danger
    Ethinyl Estradiol + Melatonin CYP inhibition

    Ethinyl Estradiol reversible_inhibitor of CYP1A2 predicted to change Melatonin AUC by ~2.97x

  • danger
    Fluvoxamine (Luvox) + Melatonin CYP inhibition

    Fluvoxamine (Luvox) reversible_inhibitor of CYP1A2 predicted to change Melatonin AUC by ~2.97x

  • danger
    Kava (Kavalactones) + Melatonin CYP inhibition

    Kava (Kavalactones) reversible_inhibitor of CYP1A2 predicted to change Melatonin AUC by ~2.97x

  • danger
    Methylene Blue + Melatonin CYP inhibition

    Methylene Blue reversible_inhibitor of CYP1A2 predicted to change Melatonin AUC by ~2.97x

Serum checks 20 modeled interaction pairings for melatonin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Meta-analysis: melatonin for the treatment of primary sleep disorders Ferracioli-Oda E et al. · PLoS ONE, 2013 DOI

    Meta-analysis of 19 RCTs found melatonin significantly reduced sleep onset latency by 7 minutes, increased total sleep time by 8 minutes, and improved overall sleep quality.

  2. Melatonin for the prevention and treatment of jet lag Herxheimer A et al. · Cochrane Database of Systematic Reviews, 2002 DOI

    Cochrane review of 10 trials found melatonin remarkably effective for preventing or reducing jet lag, particularly when crossing 5 or more time zones.

  3. Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice. Gao T, Wang Z, Dong Y, Cao J, Lin R, Wang X, Yu Z, Chen Y · Journal of pineal research, 2019 DOI

    This citation reports a laboratory or cell study involving Melatonin. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

3 published studies referenced in the app, each with a plain-language summary.