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Reishi (Ganoderma lucidum)

Adaptogenoral · inferred

Medicinal mushroom containing triterpenes (ganoderic acids) and beta-glucans. Used for immune modulation, stress resilience, and sleep quality. Triterpenes have anti-histamine and liver-protective properties. One of the most well-studied medicinal mushrooms.

Projected serum levels — 1k mg, once daily

Reishi (Ganoderma lucidum)
Reishi (Ganoderma lucidum) modeled serum levels, 1k mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 5 10 15 20 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1k mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 18.7 mg, trough ≈ 0.004 mg body load. Population-based estimate over 15 days for a 1k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Adaptogen
Route modeled
Oral
Model confidence
inferred
Half-life
1.4 h
Common dose
1k mg
Suggested maximum
3k mg/day
Reference dose range
500–3k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    7-Hydroxymitragynine (7-OH) + Reishi (Ganoderma lucidum) CYP inhibition

    Reishi (Ganoderma lucidum) reversible_inhibitor of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~2.20x

  • danger
    Alfuzosin (Uroxatral) + Reishi (Ganoderma lucidum) CYP inhibition

    Reishi (Ganoderma lucidum) reversible_inhibitor of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~3.33x

  • danger
    Alprazolam (Xanax) + Reishi (Ganoderma lucidum) CYP inhibition

    Reishi (Ganoderma lucidum) reversible_inhibitor of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~3.33x

  • danger
    Amlodipine (Norvasc) + Reishi (Ganoderma lucidum) CYP inhibition

    Reishi (Ganoderma lucidum) reversible_inhibitor of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~3.33x

  • danger
    Anastrozole (Arimidex) + Reishi (Ganoderma lucidum) CYP inhibition

    Reishi (Ganoderma lucidum) reversible_inhibitor of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~2.68x

  • danger
    Astaxanthin + Reishi (Ganoderma lucidum) CYP inhibition

    Reishi (Ganoderma lucidum) reversible_inhibitor of CYP3A4 predicted to change Astaxanthin AUC by ~3.33x

Serum checks 229 modeled interaction pairings for reishi (ganoderma lucidum) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Ganoderma Lucidum (Reishi Mushroom) for Cancer Treatment Jin X et al. · Cochrane Database of Systematic Reviews, 2012 DOI

    Cochrane review of 5 RCTs finding reishi may enhance tumor response when used alongside conventional treatment and improve host immunity.

  2. Spore Powder of Ganoderma Lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy Zhao H et al. · Evidence-Based Complementary and Alternative Medicine, 2012 DOI

    RCT showing reishi spore powder reduced cancer-related fatigue, improved quality of life, and modulated immune markers in breast cancer patients.

  3. A Randomized, Double-Blind and Placebo-Controlled Study of a Ganoderma Lucidum Polysaccharide Extract in Neurasthenia Tang W et al. · Journal of Medicinal Food, 2005 DOI

    RCT demonstrating reishi polysaccharide extract significantly reduced fatigue and improved well-being in neurasthenia patients after 8 weeks.

3 published studies referenced in the app, each with a plain-language summary.