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Glycine

Amino Acidoral · inferred

Simplest amino acid, acts as an inhibitory neurotransmitter. Supports sleep quality, collagen synthesis, and glutathione production. Half-life is dose-dependent.

Projected serum levels — 3 g (≈ 3k mg), once daily

Glycine
Glycine modeled serum levels, 3 g (≈ 3k mg) once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 625 1.3k 1.9k 2.5k Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 3 g (≈ 3k mg) once daily (oral).

Modeled steady state after ~1 days: peak ≈ 2.1k mg, trough ≈ 12.6 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Amino Acid
Route modeled
Oral
Model confidence
inferred
Half-life
3 h
Common dose
3 g (≈ 3k mg)
Suggested maximum
10 g/day
Reference dose range
1.5–10 g (single dose)
Suggested cadence
once daily

Documented interactions

  • moderate
    Taurine + Glycine Stacked effects

    Glycine and Taurine both push the endogenous amino acid pool and glycine receptor in the same direction.

  • watch
    EAAs (Essential Amino Acids) + Glycine Stacked effects

    EAAs (Essential Amino Acids) and Glycine both push the endogenous amino acid pool in the same direction.

  • watch
    Egg White Protein + Glycine Stacked effects

    Egg White Protein and Glycine both push the endogenous amino acid pool in the same direction.

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    Ethanol (Alcohol) + Glycine Stacked effects

    Ethanol (Alcohol) and Glycine both push the glycine receptor in the same direction.

  • watch
    L-Glutamine + Glycine Stacked effects

    L-Glutamine and Glycine both push the endogenous amino acid pool in the same direction.

  • watch
    Hemp Protein + Glycine Stacked effects

    Glycine and Hemp Protein both push the endogenous amino acid pool in the same direction.

Serum checks 13 modeled interaction pairings for glycine across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus Kawai N et al. · Neuropsychopharmacology, 2015 DOI

    Study elucidated the mechanism by which glycine improves sleep quality by lowering core body temperature via NMDA receptors in the brain circadian clock region.

  2. Subjective effects of glycine ingestion before bedtime on sleep quality Yamadera W et al. · Sleep and Biological Rhythms, 2007 DOI

    Clinical trial found that 3g glycine before bed significantly improved subjective sleep quality, reduced daytime sleepiness, and enhanced cognitive performance the next day.

  3. Glycine metabolism in health and disease: implications for neurological function Razak MA et al. · Frontiers in Endocrinology, 2017 DOI

    Review of glycine as a conditionally essential amino acid, highlighting its roles in glutathione synthesis, anti-inflammatory signaling, and cytoprotection.

3 published studies referenced in the app, each with a plain-language summary.