Cocaine
Tropane alkaloid and potent CNS stimulant that blocks dopamine, serotonin, and norepinephrine reuptake. Very short half-life (~1 hour) but primary metabolite benzoylecgonine persists ~6 hours and is the standard urine test target, detectable for 2-4 days.
Projected serum levels — 1 lines (≈ 50 mg), as needed (shown daily)
Maintenance schedule: 1 lines (≈ 50 mg) as needed (shown daily) (intranasal (insufflated)).
Modeled steady state after ~1 days: peak ≈ 13.4 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Stimulant
- Route modeled
- Intranasal (insufflated)
- Model confidence
- inferred
- Half-life
- 1 h
- Common dose
- 1 lines (≈ 50 mg)
- Reference dose range
- 0.50–2 lines (single dose)
- Suggested cadence
- as needed (shown daily)
- Validated against
- 100 mg insufflated — Cmax 0.20 mg/L at 0.50 h
Documented interactions
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danger
1P-LSD (1-Propionyl-LSD) + Cocaine
1P-LSD (1-Propionyl-LSD) and Cocaine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
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danger
25I-NBOMe + Cocaine
25I-NBOMe and Cocaine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
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danger
2C-I (2,5-Dimethoxy-4-iodophenethylamine) + Cocaine
2C-I (2,5-Dimethoxy-4-iodophenethylamine) and Cocaine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
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danger
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Cocaine
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) and Cocaine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
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danger
4-AcO-DMT (Psilacetin) + Cocaine
4-AcO-DMT (Psilacetin) and Cocaine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
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danger
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) + Cocaine
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine) and Cocaine both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).
Serum checks 175 modeled interaction pairings for cocaine across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.
Research behind this entry
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Pharmacokinetics and Pharmacodynamics of Cocaine
Compared cocaine pharmacokinetics across IV (25 mg), intranasal (32 mg), and smoked (42 mg) routes in six subjects, characterizing benzoylecgonine formation and elimination by each route.
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Pharmacokinetics of Cocaine and Metabolites in Human Oral Fluid and Correlation with Plasma Concentrations following Controlled Administration
Determined disposition of cocaine, benzoylecgonine, and ecgonine methyl ester in oral fluid following subcutaneous cocaine, with BE half-lives of 3.4-13.8 hours.
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A Sensitive Assay for Urinary Cocaine Metabolite Benzoylecgonine Shows More Positive Results and Longer Half-Lives than Those Using Traditional Cut-Offs
Demonstrated that using lower assay cutoffs reveals longer benzoylecgonine detection windows in urine, with terminal half-life estimates significantly longer than previously reported.
3 published studies referenced in the app, each with a plain-language summary.