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Theacrine (TeaCrine)

Nootropicoral · inferred

Purine alkaloid structurally similar to caffeine, found in Camellia kucha tea. Adenosine and dopamine receptor modulation without significant tolerance development. Substantially longer half-life (16-26h) than caffeine (3-6h). Peak plasma at ~1.8h. Does not appear to habituate with chronic use, unlike caffeine.

Projected serum levels — 200 mg, once daily

Theacrine (TeaCrine)
Theacrine (TeaCrine) modeled serum levels, 200 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 2 days. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 2
Theacrine (TeaCrine) modeled serum levels with a loading dose of 352 mg, then 200 mg once daily The first dose is larger so levels approach steady state faster. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 200 mg once daily (oral).

Loading schedule: 352 mg on day 1, then 200 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~2 days: peak ≈ 314 mg, trough ≈ 143 mg body load. Population-based estimate over 15 days for a 200 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Nootropic
Route modeled
Oral
Model confidence
inferred
Half-life
20 h
Common dose
200 mg
Suggested maximum
400 mg/day
Reference dose range
100–400 mg (single dose)
Suggested cadence
once daily
Validated against
125 mg oral — Cmax 0.40 mg/L at 1.8 h

Documented interactions

  • danger
    Apigenin + Theacrine (TeaCrine) CYP inhibition

    Apigenin reversible_inhibitor of CYP1A2 predicted to change Theacrine (TeaCrine) AUC by ~3.33x

  • danger
    Ciprofloxacin (Cipro) + Theacrine (TeaCrine) CYP inhibition

    Ciprofloxacin (Cipro) reversible_inhibitor of CYP1A2 predicted to change Theacrine (TeaCrine) AUC by ~3.33x

  • danger
    DIM (Diindolylmethane) + Theacrine (TeaCrine) CYP induction

    DIM (Diindolylmethane) inducer of CYP1A2 predicted to change Theacrine (TeaCrine) AUC by ~0.50x

  • danger
    Ethinyl Estradiol + Theacrine (TeaCrine) CYP inhibition

    Ethinyl Estradiol reversible_inhibitor of CYP1A2 predicted to change Theacrine (TeaCrine) AUC by ~3.33x

  • danger
    Fluvoxamine (Luvox) + Theacrine (TeaCrine) CYP inhibition

    Fluvoxamine (Luvox) reversible_inhibitor of CYP1A2 predicted to change Theacrine (TeaCrine) AUC by ~3.33x

  • danger
    Kava (Kavalactones) + Theacrine (TeaCrine) CYP inhibition

    Kava (Kavalactones) reversible_inhibitor of CYP1A2 predicted to change Theacrine (TeaCrine) AUC by ~3.33x

Serum checks 16 modeled interaction pairings for theacrine (teacrine) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Cognitive performance and mood following ingestion of a theacrine-containing dietary supplement, caffeine, or placebo by young men and women Ziegenfuss TN et al. · Nutrients, 2015 DOI

    RCT in 20 healthy adults found theacrine supplementation significantly improved subjective feelings of attentiveness, alertness, focus, and energy compared to placebo and caffeine, with trends for cognitive test…

  2. Assessment of the drug-drug interaction potential between theacrine and caffeine in humans He H et al. · Journal of Caffeine Research, 2017 DOI

    Pharmacokinetic study established theacrine half-life of 16.5-26.1h across 25-125 mg doses and found no significant pharmacokinetic interaction between theacrine and caffeine in humans.

  3. Dose response effects of theacrine on cognitive performance and subsequent sleep Mills BD et al. · Scientific Reports, 2024 DOI

    Dose-response study showed 200 mg theacrine significantly increased energy and reduced fatigue without impairing sleep quality, while 100 mg and 400 mg doses showed no significant cognitive effects.

3 published studies referenced in the app, each with a plain-language summary.