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Urolithin A (Mitopure)

Longevityoral · inferred

Gut-microbial metabolite of ellagitannins (from pomegranates, walnuts, berries) that induces mitophagy, clearance of dysfunctional mitochondria. Only ~40% of people produce meaningful urolithin A from dietary precursors, motivating direct supplementation (Mitopure, Timeline Nutrition). Clinically shown to improve muscle strength and mitochondrial biomarkers in older adults. GRAS-designated. Plasma half-life ~17 hours supports once-daily dosing of 250-1000 mg.

Projected serum levels — 500 mg, once daily

Urolithin A (Mitopure)
Urolithin A (Mitopure) modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 2 days. 0 50 100 150 200 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 2
Urolithin A (Mitopure) modeled serum levels with a loading dose of 855 mg, then 500 mg once daily The first dose is larger so levels approach steady state faster. 0 50 100 150 200 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 500 mg once daily (oral).

Loading schedule: 855 mg on day 1, then 500 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~2 days: peak ≈ 152 mg, trough ≈ 86.7 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Longevity
Route modeled
Oral
Model confidence
inferred
Half-life
17 h
Common dose
500 mg
Suggested maximum
1k mg/day
Reference dose range
250–1k mg (single dose)
Suggested cadence
once daily
Validated against
500 mg oral — Cmax 0.50 mg/L at 8 h

Documented interactions

  • watch
    Spermidine + Urolithin A (Mitopure) Stacked effects

    Spermidine and Urolithin A (Mitopure) both push the autophagy pathway in the same direction.

Serum checks 1 modeled interaction pairings for urolithin a (mitopure) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans Andreux PA et al. · Nature Metabolism, 2019 DOI

    First-in-human PK and safety study of urolithin A (250-2000 mg) in elderly adults: safe, bioavailable (t1/2 ~17h), and induced a skeletal muscle mitochondrial gene signature resembling exercise.

  2. Impact of the Natural Compound Urolithin A on Health, Disease, and Aging D'Amico D et al. · Trends in Molecular Medicine, 2021 DOI

    Comprehensive review of UA biology including mitophagy induction, effects on muscle function and inflammation, and translational evidence from preclinical and clinical studies.

  3. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults Liu S et al. · Cell Reports Medicine, 2022 DOI

    4-month placebo-controlled RCT in 66 middle-aged adults showed 500 and 1000 mg/day UA significantly improved leg muscle strength and aerobic endurance, supporting clinical muscle-performance benefit.

3 published studies referenced in the app, each with a plain-language summary.