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Rhodiola Rosea

Adaptogenoral · inferred

Adaptogenic herb with active compounds salidroside and rosavin. Reduces mental fatigue, improves stress resilience, and may inhibit MAO. Effects felt within 25 minutes.

Projected serum levels — 400 mg, once daily

Rhodiola Rosea
Rhodiola Rosea modeled serum levels, 400 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 50 100 150 200 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 400 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 116 mg, trough ≈ 0.077 mg body load. Population-based estimate over 15 days for a 400 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Adaptogen
Route modeled
Oral
Model confidence
inferred
Half-life
2 h
Common dose
400 mg
Suggested maximum
1k mg/day
Reference dose range
200–1k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    1P-LSD (1-Propionyl-LSD) + Rhodiola Rosea Serotonin risk

    1P-LSD (1-Propionyl-LSD) and Rhodiola Rosea both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    25I-NBOMe + Rhodiola Rosea Serotonin risk

    25I-NBOMe and Rhodiola Rosea both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    2C-I (2,5-Dimethoxy-4-iodophenethylamine) + Rhodiola Rosea Serotonin risk

    2C-I (2,5-Dimethoxy-4-iodophenethylamine) and Rhodiola Rosea both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Rhodiola Rosea Serotonin risk

    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) and Rhodiola Rosea both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    3-MeO-PCP (3-Methoxyphencyclidine) + Rhodiola Rosea Serotonin risk

    3-MeO-PCP (3-Methoxyphencyclidine) and Rhodiola Rosea both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    4-AcO-DMT (Psilacetin) + Rhodiola Rosea Serotonin risk

    4-AcO-DMT (Psilacetin) and Rhodiola Rosea both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

Serum checks 325 modeled interaction pairings for rhodiola rosea across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Rhodiola rosea in stress induced fatigue - a double blind cross-over study of a standardized extract SHR-5 Darbinyan V et al. · Phytomedicine, 2000 DOI

    Double-blind crossover trial in physicians during night duty found Rhodiola rosea extract significantly improved mental performance, attention, and reduced mental fatigue.

  2. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue Olsson EM et al. · Planta Medica, 2009 DOI

    RCT found Rhodiola rosea (576 mg/day for 28 days) significantly improved attention, quality of life, and reduced fatigue and cortisol response in stressed individuals.

  3. Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention Li Y et al. · Current Pharmacology Reports, 2017 DOI

    Review of Rhodiola rosea pharmacology showing adaptogenic, neuroprotective, and anti-cancer properties mediated through AMPK, SIRT1, and Nrf2 pathways.

3 published studies referenced in the app, each with a plain-language summary.