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Peyote (Mescaline Cactus)

Psychedelicoral · inferred

Small spineless cactus (Lophophora williamsii) containing mescaline as the primary active alkaloid. Sacred to Native American Church. Slower onset (1-2h) compared to synthetic mescaline due to plant matrix digestion, but same pharmacology. Effects last 10-12 hours. Also contains minor alkaloids (pellotine, anhalonidine) that may modulate the experience.

Projected serum levels — 6 buttons (≈ 210 mg), as needed (shown daily)

Peyote (Mescaline Cactus)
Peyote (Mescaline Cactus) modeled serum levels, 6 buttons (≈ 210 mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 25 50 75 100 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 6 buttons (≈ 210 mg) as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 55.8 mg, trough ≈ 0.47 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Psychedelic
Route modeled
Oral
Model confidence
inferred
Half-life
2.5 h
Common dose
6 buttons (≈ 210 mg)
Reference dose range
3–12 buttons (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • danger
    1P-LSD (1-Propionyl-LSD) + Peyote (Mescaline Cactus) Serotonin risk

    1P-LSD (1-Propionyl-LSD) and Peyote (Mescaline Cactus) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    25I-NBOMe + Peyote (Mescaline Cactus) Serotonin risk

    25I-NBOMe and Peyote (Mescaline Cactus) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    2C-I (2,5-Dimethoxy-4-iodophenethylamine) + Peyote (Mescaline Cactus) Serotonin risk

    2C-I (2,5-Dimethoxy-4-iodophenethylamine) and Peyote (Mescaline Cactus) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…

  • danger
    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Peyote (Mescaline Cactus) Serotonin risk

    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) and Peyote (Mescaline Cactus) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental…

  • danger
    3-MeO-PCP (3-Methoxyphencyclidine) + Peyote (Mescaline Cactus) Serotonin risk

    3-MeO-PCP (3-Methoxyphencyclidine) and Peyote (Mescaline Cactus) both have serotonergic activity. Risk of serotonin syndrome (hyperthermia, rigidity, autonomic instability, altered mental status).

  • danger
    4-AcO-DMT (Psilacetin) + Peyote (Mescaline Cactus) Stacked effects

    4-AcO-DMT (Psilacetin) and Peyote (Mescaline Cactus) both push the serotonin 5HT1A, serotonin 5HT2A, and serotonin 5HT2C in the same direction.

Serum checks 129 modeled interaction pairings for peyote (mescaline cactus) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions Dinis-Oliveira RJ et al. · Current Molecular Pharmacology, 2019 DOI

    Review of peyote pharmacology covering mescaline absorption from cactus matrix, metabolism via MAO and COMT, and clinical/forensic detection considerations.

1 published study referenced in the app, each with a plain-language summary.