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PCP (Phencyclidine)

Dissociativeoral · inferred

NMDA receptor antagonist and dissociative anesthetic. Highly lipophilic with large volume of distribution, leading to prolonged effects and detection window. Half-life ~21 hours but can extend to 72 hours at overdose. Detectable in urine for 1-2 weeks in chronic users.

Projected serum levels — 5 mg, as needed (shown daily)

PCP (Phencyclidine)
PCP (Phencyclidine) modeled serum levels, 5 mg as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 3 days. 0 2.5 5 7.5 10 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 3
PCP (Phencyclidine) modeled serum levels with a loading dose of 11.4 mg, then 5 mg as needed (shown daily) The first dose is larger so levels approach steady state faster. 0 2.5 5 7.5 10 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 5 mg as needed (shown daily) (oral).

Loading schedule: 11.4 mg on day 1, then 5 mg as needed (shown daily) — reaching therapeutic levels sooner.

Modeled steady state after ~3 days: peak ≈ 7.5 mg, trough ≈ 4.5 mg body load. Population-based estimate over 15 days for a 5 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Dissociative
Route modeled
Oral
Model confidence
inferred
Half-life
20 h
Common dose
5 mg
Reference dose range
2.5–10 mg (single dose)
Suggested cadence
as needed (shown daily)
Validated against
5 mg oral — Cmax 0.007 mg/L at 1.5 h

Documented interactions

  • contraindicated
    Efavirenz (Sustiva) + PCP (Phencyclidine) CYP induction

    Efavirenz (Sustiva) inducer of CYP3A4 predicted to change PCP (Phencyclidine) AUC by ~0.19x

  • contraindicated
    Rifampin + PCP (Phencyclidine) CYP induction

    Rifampin inducer of CYP3A4 predicted to change PCP (Phencyclidine) AUC by ~0.19x

  • danger
    Amphetamine (Adderall) + PCP (Phencyclidine) Contraindicated

    PCP + stimulants causes extreme cardiovascular strain, psychosis, hyperthermia, and seizure risk.

  • danger
    Carbamazepine (Tegretol) + PCP (Phencyclidine) CYP induction

    Carbamazepine (Tegretol) inducer of CYP3A4 predicted to change PCP (Phencyclidine) AUC by ~0.29x

  • danger
    Clarithromycin (Biaxin) + PCP (Phencyclidine) CYP inhibition

    Clarithromycin (Biaxin) mechanism_based of CYP3A4 predicted to change PCP (Phencyclidine) AUC by ~2.29x

  • danger
    Cocaine + PCP (Phencyclidine) Contraindicated

    PCP + cocaine causes severe cardiovascular strain, psychosis, and seizure risk.

Serum checks 103 modeled interaction pairings for pcp (phencyclidine) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Phencyclidine Disposition after Intravenous and Oral Doses Cook CE et al. · Clinical Pharmacology & Therapeutics, 1982 DOI

    Administered radiolabeled PCP IV and orally to healthy men, finding 73% urinary recovery, 16% as unchanged PCP, with hydroxylated metabolite conjugates comprising 31% of urinary radioactivity.

  2. Urine pH and Phencyclidine Excretion Perez-Reyes M et al. · Clinical Pharmacology & Therapeutics, 1982 DOI

    Showed acidification of urine dramatically increased PCP renal clearance compared to alkaline urine, supporting ion-trapping mechanism for this weak base (pKa 8.5).

2 published studies referenced in the app, each with a plain-language summary.