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Rifampin

Prescriptionprescriptionoral · inferred

Potent broad-spectrum antibiotic used primarily for tuberculosis (in combination) and latent TB. Also used for staphylococcal infections, leprosy, and prophylaxis of meningococcal disease. Rifampin is the prototypical broad-spectrum CYP enzyme and transporter inducer via PXR activation.

Projected serum levels — 600 mg, once daily

Rifampin
Rifampin modeled serum levels, 600 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 600 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 361 mg, trough ≈ 6.7 mg body load. Population-based estimate over 15 days for a 600 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Prescription
Route modeled
Oral
Model confidence
inferred
Half-life
3.5 h
Common dose
600 mg
Suggested maximum
600 mg/day
Reference dose range
150–600 mg (single dose)
Suggested cadence
once daily
Validated against
600 mg oral — Cmax 12 mg/L at 2.5 h

Documented interactions

  • contraindicated
    7-Hydroxymitragynine (7-OH) + Rifampin CYP induction

    Rifampin inducer of CYP3A4 predicted to change 7-Hydroxymitragynine (7-OH) AUC by ~0.16x

  • contraindicated
    Albendazole (Albenza) + Rifampin CYP induction

    Rifampin inducer of CYP3A4 predicted to change Albendazole (Albenza) AUC by ~0.18x

  • contraindicated
    Alfuzosin (Uroxatral) + Rifampin CYP induction

    Rifampin inducer of CYP3A4 predicted to change Alfuzosin (Uroxatral) AUC by ~0.12x

  • contraindicated
    Alprazolam (Xanax) + Rifampin CYP induction

    Rifampin inducer of CYP3A4 predicted to change Alprazolam (Xanax) AUC by ~0.12x

  • contraindicated
    Amlodipine (Norvasc) + Rifampin CYP induction

    Rifampin inducer of CYP3A4 predicted to change Amlodipine (Norvasc) AUC by ~0.12x

  • contraindicated
    Anastrozole (Arimidex) + Rifampin CYP induction

    Rifampin inducer of CYP3A4 predicted to change Anastrozole (Arimidex) AUC by ~0.14x

Serum checks 554 modeled interaction pairings for rifampin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Rifampin and rifabutin drug interactions: an update Baciewicz AM et al. · Archives of Internal Medicine, 2008 DOI

    Comprehensive review of rifamycin drug interactions, documenting clinically significant induction effects on contraceptives, warfarin, cyclosporine, and antiretrovirals.

1 published study referenced in the app, each with a plain-language summary.