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Amphetamine (Adderall)

Stimulantprescriptionoral · inferred

Mixed amphetamine salts (75% d-amphetamine, 25% l-amphetamine) for ADHD. d-isomer has shorter half-life (~10h) than l-isomer (~13h). Urinary pH significantly affects elimination.

Projected serum levels — 20 mg, once daily

Amphetamine (Adderall)
Amphetamine (Adderall) modeled serum levels, 20 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 5 10 15 20 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 20 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 11.6 mg, trough ≈ 0.097 mg body load. Population-based estimate over 15 days for a 20 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Stimulant
Route modeled
Oral
Model confidence
inferred
Half-life
3 h
Common dose
20 mg
Suggested maximum
60 mg/day
Reference dose range
5–60 mg (single dose)
Suggested cadence
once daily

Documented interactions

  • danger
    Ayahuasca (DMT + Harmaline) + Amphetamine (Adderall) Contraindicated

    Ayahuasca MAO inhibitors prevent breakdown of catecholamines released by amphetamine. Results in severe hypertensive crisis, hyperthermia, and potentially fatal cardiovascular events.

  • danger
    Berberine + Amphetamine (Adderall) CYP inhibition

    Berberine reversible_inhibitor of CYP2D6 predicted to change Amphetamine (Adderall) AUC by ~2.11x

  • danger
    Bupropion (Wellbutrin) + Amphetamine (Adderall) CYP inhibition

    Bupropion (Wellbutrin) reversible_inhibitor of CYP2D6 predicted to change Amphetamine (Adderall) AUC by ~2.11x

  • danger
    CBD (Cannabidiol) + Amphetamine (Adderall) CYP inhibition

    CBD (Cannabidiol) reversible_inhibitor of CYP2D6 predicted to change Amphetamine (Adderall) AUC by ~2.11x

  • danger
    Celecoxib (Celebrex) + Amphetamine (Adderall) CYP inhibition

    Celecoxib (Celebrex) reversible_inhibitor of CYP2D6 predicted to change Amphetamine (Adderall) AUC by ~2.11x

  • danger
    Citalopram (Celexa) + Amphetamine (Adderall) CYP inhibition

    Citalopram (Celexa) reversible_inhibitor of CYP2D6 predicted to change Amphetamine (Adderall) AUC by ~2.11x

Serum checks 45 modeled interaction pairings for amphetamine (adderall) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder (MTA Study) MTA Cooperative Group · Archives of General Psychiatry, 1999 DOI

    Landmark NIMH trial of 579 children found carefully managed medication (primarily mixed amphetamine salts) was superior to behavioral treatment and community care for ADHD core symptoms.

  2. Amphetamines for attention deficit hyperactivity disorder (ADHD) in adults Castells X et al. · Cochrane Database of Systematic Reviews, 2018 DOI

    Cochrane review found amphetamines are effective for treating adult ADHD, significantly reducing ADHD symptom severity with moderate evidence for short-term improvement.

  3. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis Cortese S et al. · Lancet Psychiatry, 2018 DOI

    Network meta-analysis of 133 RCTs identified amphetamines as the preferred first-choice ADHD pharmacotherapy in adults (best efficacy-tolerability balance); methylphenidate preferred in children.

3 published studies referenced in the app, each with a plain-language summary.