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Glutathione (Injectable)

Peptideiv · inferred

Injectable form of the tripeptide glutathione (Glu-Cys-Gly), the body's primary endogenous antioxidant. IV elimination half-life ~14 minutes with rapid oxidation to GSSG. Administered IV or IM for antioxidant support, detoxification, and skin brightening. Despite very short half-life, replenishes intracellular glutathione stores for prolonged effect.

Projected serum levels — 600 mg, weekly

Glutathione (Injectable)
Glutathione (Injectable) modeled serum levels, 600 mg weekly over 21 days Population-based pharmacokinetic estimate. Steady state reached after approximately 7 days. 0 250 500 750 1k Day 0 Day 5 Day 11 Day 16 Day 21 Time on a regular schedule ≈ steady state · day 7

Maintenance schedule: 600 mg weekly (iv).

Modeled steady state after ~7 days: peak ≈ 72.6 mg, trough ≈ 0.000 mg body load. Population-based estimate over 21 days for a 600 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
IV
Model confidence
inferred
Half-life
14 min
Common dose
600 mg
Suggested maximum
2k mg/day
Reference dose range
300–2k mg (single dose)
Suggested cadence
weekly

Documented interactions

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    Astaxanthin + Glutathione (Injectable) Stacked effects

    Astaxanthin and Glutathione (Injectable) both push the nrf2 in the same direction.

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    Black Seed Oil (Nigella sativa / Thymoquinone) + Glutathione (Injectable) Stacked effects

    Black Seed Oil (Nigella sativa / Thymoquinone) and Glutathione (Injectable) both push the nrf2 in the same direction.

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    Dimethyl Fumarate (Tecfidera) + Glutathione (Injectable) Stacked effects

    Dimethyl Fumarate (Tecfidera) and Glutathione (Injectable) both push the nrf2 in the same direction.

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    Green Tea Extract (Camellia sinensis) + Glutathione (Injectable) Stacked effects

    Glutathione (Injectable) and Green Tea Extract (Camellia sinensis) both push the nrf2 in the same direction.

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    Milk Thistle (Silymarin / Silybin) + Glutathione (Injectable) Stacked effects

    Glutathione (Injectable) and Milk Thistle (Silymarin / Silybin) both push the endogenous glutathione pool in the same direction.

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    N-Acetyl Cysteine (NAC) + Glutathione (Injectable) Stacked effects

    Glutathione (Injectable) and N-Acetyl Cysteine (NAC) both push the endogenous glutathione pool in the same direction.

Serum checks 12 modeled interaction pairings for glutathione (injectable) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. High-dose intravenous glutathione in man: pharmacokinetics and effects on cyst(e)ine in plasma and urine Aebi S et al. · European Journal of Clinical Investigation, 1991 DOI

    Key human PK study showing IV glutathione elimination half-life of 14.1 +/- 9.2 min with rapid appearance of cysteine and cystine metabolites in plasma, establishing the basis for IV glutathione dosing.

  2. Pharmacokinetics of Glutathione and Its Metabolites in Normal Subjects Berk M et al. · Journal of Clinical Psychopharmacology, 2008 DOI

    Characterized glutathione and metabolite pharmacokinetics in healthy volunteers, establishing baseline parameters for therapeutic glutathione administration.

2 published studies referenced in the app, each with a plain-language summary.