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GHRP-6

Peptidesubcutaneous · inferred

First-generation growth hormone releasing hexapeptide. Stimulates GH release via ghrelin receptor (GHS-R1a). Notably increases appetite (strong ghrelin effect). Half-life ~2.5 hours. Dosed 100-300 mcg SC 2-3x/day on empty stomach. Often combined with GHRH for amplified GH pulse.

Projected serum levels — 100 mcg (≈ 0.10 mg), twice daily

GHRP-6
GHRP-6 modeled serum levels, 100 mcg (≈ 0.10 mg) twice daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 7 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 100 mcg (≈ 0.10 mg) twice daily (subcutaneous).

Modeled steady state after ~1 days: peak ≈ 0.041 mg, trough ≈ 0.003 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
Subcutaneous
Model confidence
inferred
Half-life
2.5 h
Common dose
100 mcg (≈ 0.10 mg)
Suggested maximum
300 mcg/day
Reference dose range
50–300 mcg (single dose)
Suggested cadence
twice daily

Documented interactions

  • caution
    GHRP-2 (Pralmorelin) + GHRP-6 Potentiation

    Both are ghrelin receptor agonists. Stacking two GHRPs provides diminishing returns as they compete for the same receptor.

  • caution
    Ipamorelin + GHRP-6 Potentiation

    Both are GH secretagogues. Stacking provides diminishing returns.

  • watch
    BPC-157 (Body Protection Compound) + GHRP-6 Stacked effects

    BPC-157 (Body Protection Compound) and GHRP-6 both push the growth hormone receptor in the same direction.

  • watch
    HGH (Human Growth Hormone / Somatropin) + GHRP-6 Stacked effects

    GHRP-6 and HGH (Human Growth Hormone / Somatropin) both push the growth hormone receptor in the same direction.

  • watch
    Ibutamoren (MK-677) + GHRP-6 Stacked effects

    GHRP-6 and Ibutamoren (MK-677) both push the ghrelin receptor in the same direction.

Serum checks 7 modeled interaction pairings for ghrp-6 across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers Cabrales A et al. · European Journal of Pharmaceutical Sciences, 2013 DOI

    PK study in 9 healthy men (PMID:23099431) showing GHRP-6 distribution half-life of 7.6 min and elimination half-life of ~2.5 h after SC injection; absorption rapid with Tmax ~5-15 min.

  2. Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects Berlanga-Acosta J et al. · Clinical Medicine Insights: Cardiology, 2017 DOI

    Review of GHRP-6 cytoprotective effects beyond GH release, including cardioprotection, neuroprotection, and anti-inflammatory activity mediated through CD36 receptor.

  3. Growth Hormone Secretagogues: History, Mechanism of Action, and Clinical Development Ishida J et al. · JCSM Rapid Communications, 2020 DOI

    Review covering GHRP-6 as the prototype GH secretagogue, its ghrelin receptor mechanism, appetite-stimulating side effects, and evolution to newer analogs.

3 published studies referenced in the app, each with a plain-language summary.