Epinephrine (Adrenalin)

Catecholamineprescriptionim · inferred

Endogenous catecholamine and potent non-selective alpha/beta adrenergic agonist used in emergency settings for anaphylaxis (IM 0.3 mg), cardiac arrest (IV 1 mg q3-5min), and severe asthma. Rapid COMT/MAO-mediated metabolism with an elimination half-life of only 2-3 minutes. Naturally produced by the adrenal medulla at very low basal levels.

Projected serum levels — 0.30 mg, as needed (shown daily)

Maintenance schedule: 0.30 mg as needed (shown daily) (im).

Modeled steady state after ~1 days: peak ≈ 0.001 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 0.30 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category: Catecholamine
Route modeled: IM
Model confidence: inferred
Half-life: 3 min
Common dose: 0.30 mg
Suggested maximum: 1 mg/day
Reference dose range: 0.10–1 mg (single dose)
Suggested cadence: as needed (shown daily)
Validated against: 0.30 mg im — Cmax 0.000 mg/L at 0.15 h

Documented interactions

danger
Pseudoephedrine (Sudafed) + Epinephrine (Adrenalin) Stacked effects
Epinephrine (Adrenalin) and Pseudoephedrine (Sudafed) both push the alpha1 adrenergic, alpha2 adrenergic, and beta2 adrenergic in the same direction.
moderate
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) + Epinephrine (Adrenalin) CYP inhibition
2C-B (4-Bromo-2,5-dimethoxyphenethylamine) reversible_inhibitor of MAO-A predicted to change Epinephrine (Adrenalin) AUC by ~1.27x
moderate
Albuterol (ProAir / Ventolin / Proventil) + Epinephrine (Adrenalin) Stacked effects
Albuterol (ProAir / Ventolin / Proventil) and Epinephrine (Adrenalin) both push the beta1 adrenergic and beta2 adrenergic in the same direction.
moderate
Green Tea Extract (Camellia sinensis) + Epinephrine (Adrenalin) CYP inhibition
Green Tea Extract (Camellia sinensis) reversible_inhibitor of COMT predicted to change Epinephrine (Adrenalin) AUC by ~1.96x
watch
Kratom (Mitragynine) + Epinephrine (Adrenalin) Stacked effects
Epinephrine (Adrenalin) and Kratom (Mitragynine) both push the alpha2 adrenergic in the same direction.
watch
Mirabegron (Myrbetriq) + Epinephrine (Adrenalin) Stacked effects
Epinephrine (Adrenalin) and Mirabegron (Myrbetriq) both push the beta1 adrenergic in the same direction.

Serum checks 7 modeled interaction pairings for epinephrine (adrenalin) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

Epinephrine absorption in adults: intramuscular versus subcutaneous injection Simons FER et al. · Journal of Allergy and Clinical Immunology, 2001 DOI
Pivotal PK study demonstrating that IM injection into the thigh (vastus lateralis) produces significantly faster and higher peak plasma epinephrine concentrations than subcutaneous administration, establishing IM as the…
Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology Muraro A et al. · Allergy, 2014 DOI
Comprehensive international guideline establishing IM epinephrine 0.3-0.5 mg as first-line anaphylaxis treatment with emphasis on early administration and the critical importance of the vastus lateralis injection site…
Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Link MS et al. · Circulation, 2015 DOI
AHA ACLS guidelines establishing IV/IO epinephrine 1 mg every 3-5 minutes as standard for cardiac arrest with nonshockable rhythms, documenting improved ROSC and survival to hospital admission.

3 published studies referenced in the app, each with a plain-language summary.