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Albuterol (ProAir / Ventolin / Proventil)

Short-Acting Beta-2 Agonist (SABA)prescriptionoral · inferred

Short-acting beta-2 adrenergic agonist (rescue inhaler) for acute bronchospasm and asthma. Inhaled onset within 5 minutes, duration 4-6 hours. Also known as salbutamol internationally. Metabolized by oxidative deamination; ~70% excreted renally within 24 hours.

Projected serum levels — 2 puffs (≈ 0.18 mg), as needed (shown daily)

Albuterol (ProAir / Ventolin / Proventil)
Albuterol (ProAir / Ventolin / Proventil) modeled serum levels, 2 puffs (≈ 0.18 mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 2 puffs (≈ 0.18 mg) as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 0.071 mg, trough ≈ 0.001 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Short-Acting Beta-2 Agonist (SABA)
Route modeled
Oral
Model confidence
inferred
Half-life
5 h
Common dose
2 puffs (≈ 0.18 mg)
Suggested maximum
12 puffs/day
Reference dose range
1–12 puffs (single dose)
Suggested cadence
as needed (shown daily)
Validated against
4 mg oral — Cmax 0.018 mg/L at 2.5 h

Documented interactions

  • moderate
    Epinephrine (Adrenalin) + Albuterol (ProAir / Ventolin / Proventil) Stacked effects

    Albuterol (ProAir / Ventolin / Proventil) and Epinephrine (Adrenalin) both push the beta1 adrenergic and beta2 adrenergic in the same direction.

  • watch
    Mirabegron (Myrbetriq) + Albuterol (ProAir / Ventolin / Proventil) Stacked effects

    Albuterol (ProAir / Ventolin / Proventil) and Mirabegron (Myrbetriq) both push the beta1 adrenergic in the same direction.

  • watch
    Pseudoephedrine (Sudafed) + Albuterol (ProAir / Ventolin / Proventil) Stacked effects

    Albuterol (ProAir / Ventolin / Proventil) and Pseudoephedrine (Sudafed) both push the beta2 adrenergic in the same direction.

Serum checks 3 modeled interaction pairings for albuterol (proair / ventolin / proventil) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Active albuterol or placebo, sham acupuncture, or no intervention in asthma Wechsler ME et al. · New England Journal of Medicine, 2011 DOI

    NEJM trial in 46 asthma patients demonstrated albuterol produced a 20% improvement in FEV1 versus 7% for placebo, though subjective symptom improvement was similar across all groups.

  2. Albuterol-budesonide fixed-dose combination rescue inhaler for asthma Papi A et al. · New England Journal of Medicine, 2022 DOI

    Phase 3 trial of 3,132 patients with uncontrolled moderate-to-severe asthma found albuterol-budesonide rescue inhaler reduced severe exacerbation risk by 26% versus albuterol alone.

  3. Regular inhaled salbutamol and asthma control: the TRUST randomised trial Dennis SM et al. · Lancet, 2000 DOI

    RCT of 983 patients found regular scheduled salbutamol use provided no benefit over as-needed use, supporting current guidelines recommending rescue-only SABA therapy.

3 published studies referenced in the app, each with a plain-language summary.