Zinc (Picolinate)
Essential trace mineral for immune function, wound healing, protein synthesis, and taste/smell. Picolinate form offers superior absorption.
Projected serum levels — 15 mg, once daily
Maintenance schedule: 15 mg once daily (oral).
Loading schedule: 45 mg on day 1, then 15 mg once daily — reaching therapeutic levels sooner.
Modeled steady state after ~95 days: peak ≈ 265 mg, trough ≈ 262 mg body load. Population-based estimate over 121 days for a 15 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Mineral
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 50 days
- Common dose
- 15 mg
- Suggested maximum
- 40 mg/day
- Reference dose range
- 7.5–40 mg (single dose)
- Suggested cadence
- once daily
- Validated against
- 50 mg oral — Cmax 1.5 mg/L at 2.5 h
Documented interactions
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danger
Levothyroxine (Synthroid) + Zinc (Picolinate)
Zinc (Picolinate) may displace Levothyroxine (Synthroid) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration…
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danger
Tacrolimus (Prograf) + Zinc (Picolinate)
Zinc (Picolinate) may displace Tacrolimus (Prograf) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration…
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danger
Warfarin (Coumadin) + Zinc (Picolinate)
Zinc (Picolinate) may displace Warfarin (Coumadin) from plasma protein binding sites, transiently raising free drug concentration. This drug has a narrow therapeutic index; free concentration changes…
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warning
Apigenin + Zinc (Picolinate)
Apigenin may displace Zinc (Picolinate) from plasma protein binding sites, transiently raising free drug concentration.
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warning
Aripiprazole (Abilify) + Zinc (Picolinate)
Zinc (Picolinate) may displace Aripiprazole (Abilify) from plasma protein binding sites, transiently raising free drug concentration.
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warning
Armour Thyroid (Desiccated Thyroid Extract) + Zinc (Picolinate)
Zinc (Picolinate) may displace Armour Thyroid (Desiccated Thyroid Extract) from plasma protein binding sites, transiently raising free drug concentration.
Serum checks 150 modeled interaction pairings for zinc (picolinate) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.
Research behind this entry
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Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate
Meta-analysis found zinc lozenges shortened common cold duration by approximately 33%, with zinc acetate lozenges being more effective than gluconate.
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Discovery of human zinc deficiency: its impact on human health and disease
Comprehensive review by the discoverer of human zinc deficiency documenting its role in immune function, growth, and over 300 enzymatic processes.
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Zinc supplementation for improving pregnancy and infant outcome
Cochrane review of 21 trials found zinc supplementation during pregnancy reduced preterm birth by 14%.
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[Effect of different concentrations of various zinc complexes (picolinate, citrate, 8-hydroxyquinolate) in comparison with sulfate on zinc supply status in rats].
This citation reports an animal study involving Zinc (Picolinate). It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.
5 published studies referenced in the app, each with a plain-language summary.