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Folate (Methylfolate / B9)

Vitaminoral · inferred

Essential for DNA synthesis and cell division. The methylfolate form is the bioactive form that bypasses MTHFR variants.

Projected serum levels — 400 mcg (≈ 0.40 mg), once daily

Folate (Methylfolate / B9)
Folate (Methylfolate / B9) modeled serum levels, 400 mcg (≈ 0.40 mg) once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 400 mcg (≈ 0.40 mg) once daily (oral).

Modeled steady state after ~1 days: peak ≈ 0.31 mg, trough ≈ 0.013 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Vitamin
Route modeled
Oral
Model confidence
inferred
Half-life
5 h
Common dose
400 mcg (≈ 0.40 mg)
Suggested maximum
1k mcg/day
Reference dose range
200–1k mcg (single dose)
Suggested cadence
once daily
Validated against
1 mg oral — Cmax 0.044 mg/L at 1 h

Documented interactions

  • caution
    Combined OC (Drospirenone / Ethinyl Estradiol) + Folate (Methylfolate / B9) Depletion

    Combined oral contraceptives reduce folate levels.

  • caution
    Combined OC (Levonorgestrel / Ethinyl Estradiol) + Folate (Methylfolate / B9) Depletion

    Combined oral contraceptives reduce folate levels. Critical if planning pregnancy.

  • caution
    Ethanol (Alcohol) + Folate (Methylfolate / B9) Depletion

    Alcohol impairs folate absorption and increases urinary excretion.

  • caution
    Metformin + Folate (Methylfolate / B9) Depletion

    Metformin can reduce folate absorption through similar mechanisms as B12 depletion.

  • watch
    Vitamin B12 (Cobalamin) + Folate (Methylfolate / B9) Stacked effects

    Folate (Methylfolate / B9) and Vitamin B12 (Cobalamin) both push the folate pool in the same direction.

Serum checks 5 modeled interaction pairings for folate (methylfolate / b9) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study MRC Vitamin Study Research Group · Lancet, 1991 DOI

    Landmark RCT demonstrating that folic acid supplementation before and during early pregnancy reduced neural tube defects by 72%.

1 published study referenced in the app, each with a plain-language summary.