Salicylic Acid

NSAID active/metaboliteprescription

Hydrolyzed metabolite of aspirin; contributes most COX inhibition after the initial platelet acetylation event. Also a direct topical keratolytic.

Pharmacokinetic model

A route-level PK model for salicylic acid is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: NSAID active/metabolite
Half-life: 3 h
Reference dose range: 1–8 mg (single dose)
Suggested cadence: custom (shown daily)
Validated against: 1k mg oral — Cmax 65 mg/L at 1 h

Documented interactions

moderate
5-Aminosalicylic Acid (Mesalamine) + Salicylic Acid Stacked effects
5-Aminosalicylic Acid (Mesalamine) and Salicylic Acid both push the cox1 and cox2 in the same direction.
moderate
Aspirin (Acetylsalicylic Acid) + Salicylic Acid Stacked effects
Aspirin (Acetylsalicylic Acid) and Salicylic Acid both push the cox1 and cox2 in the same direction.
moderate
Celecoxib (Celebrex) + Salicylic Acid Stacked effects
Celecoxib (Celebrex) and Salicylic Acid both push the cox1 and cox2 in the same direction.
moderate
Diclofenac (Voltaren) + Salicylic Acid Stacked effects
Diclofenac (Voltaren) and Salicylic Acid both push the cox1 and cox2 in the same direction.
moderate
Meloxicam (Mobic) + Salicylic Acid Stacked effects
Meloxicam (Mobic) and Salicylic Acid both push the cox1 and cox2 in the same direction.
moderate
Mesalamine / 5-ASA (Lialda/Apriso/Pentasa) + Salicylic Acid Stacked effects
Mesalamine / 5-ASA (Lialda/Apriso/Pentasa) and Salicylic Acid both push the cox1 and cox2 in the same direction.

Serum checks 11 modeled interaction pairings for salicylic acid across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.