Home › Compound Library › Aspirin (Acetylsalicylic Acid)

Aspirin (Acetylsalicylic Acid)

Analgesicoral · inferred

NSAID and antiplatelet agent. Aspirin itself has a very short half-life (~20 min) but is rapidly converted to salicylic acid which persists longer. Irreversibly inhibits COX.

Projected serum levels — 325 mg, as needed (shown daily)

Aspirin (Acetylsalicylic Acid) (precursor)Salicylic Acid
Aspirin (Acetylsalicylic Acid) modeled serum levels, 325 mg as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 25 50 75 100 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 325 mg as needed (shown daily) (oral).

Modeled steady state after ~1 days: peak ≈ 53.1 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 325 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Analgesic
Route modeled
Oral
Model confidence
inferred
Half-life
2.5 h
Common dose
325 mg
Suggested maximum
4k mg/day
Reference dose range
75–4k mg (single dose)
Suggested cadence
as needed (shown daily)
Validated against
650 mg oral — Cmax 50 mg/L at 1 h

Documented interactions

  • danger
    Naproxen (Aleve) + Aspirin (Acetylsalicylic Acid) Stacked effects

    Aspirin (Acetylsalicylic Acid) and Naproxen (Aleve) both push the cox1, cox1 platelet, and cox2 in the same direction.

  • warning
    Bumetanide (Bumex) + Aspirin (Acetylsalicylic Acid) Depletion

    NSAID reduces diuretic effect.

  • warning
    Furosemide (Lasix) + Aspirin (Acetylsalicylic Acid) Depletion

    NSAIDs reduce diuretic efficacy via inhibition of renal prostaglandin synthesis; also increases renal dysfunction risk.

  • warning
    Ginkgo Biloba (EGb 761) + Aspirin (Acetylsalicylic Acid) Potentiation

    Ginkgo biloba contains ginkgolides that antagonise platelet-activating factor (PAF). Combined with aspirin (COX inhibitor), the antiplatelet effect is compounded, significantly increasing bleeding…

  • warning
    Ibuprofen (Advil / Motrin) + Aspirin (Acetylsalicylic Acid) Contraindicated

    Multiple NSAIDs together greatly increase GI bleeding and kidney injury risk without additional benefit.

  • warning
    Piracetam + Aspirin (Acetylsalicylic Acid) Potentiation

    Piracetam has antiplatelet and antithrombotic properties (reduces platelet aggregation, improves erythrocyte deformability). Combined with aspirin, bleeding risk may be increased.

Serum checks 31 modeled interaction pairings for aspirin (acetylsalicylic acid) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials Antithrombotic Trialists Collaboration · Lancet, 2009 DOI

    Meta-analysis of 95,000 participants in primary prevention and 17,000 in secondary prevention found aspirin reduced serious vascular events by 12% in primary and 19% in secondary prevention.

  2. Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials Seshasai SR et al. · Archives of Internal Medicine, 2012 DOI

    Meta-analysis of 9 trials involving 100,000+ individuals found aspirin reduced nonfatal MI by 20% but increased bleeding events, with uncertain net benefit in primary prevention.

  3. Effect of aspirin on cancer incidence and mortality: a systematic review and meta-analysis Rothwell PM et al. · Lancet, 2012 DOI

    Pooled analysis of 51 trials found daily aspirin use reduced cancer mortality by 15% at 5 years and 37% at 20 years, with strongest effects for colorectal cancer.

3 published studies referenced in the app, each with a plain-language summary.