5-Aminosalicylic Acid (Mesalamine)
5-ASA; active metabolite of sulfasalazine and a commercial drug (Pentasa, Asacol) in its own right. Acts locally in colonic lumen.
Pharmacokinetic model
A route-level PK model for 5-aminosalicylic acid (mesalamine) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Anti-inflammatory metabolite
- Half-life
- 1 h
- Reference dose range
- 1–8 mg (single dose)
- Suggested cadence
- custom (shown daily)
- Validated against
- 800 mg oral — Cmax 1.5 mg/L at 4 h
Documented interactions
-
danger
Mesalamine / 5-ASA (Lialda/Apriso/Pentasa) + 5-Aminosalicylic Acid (Mesalamine)
5-Aminosalicylic Acid (Mesalamine) and Mesalamine / 5-ASA (Lialda/Apriso/Pentasa) both push the cox1, cox2, and ppar gamma in the same direction.
-
moderate
Aspirin (Acetylsalicylic Acid) + 5-Aminosalicylic Acid (Mesalamine)
5-Aminosalicylic Acid (Mesalamine) and Aspirin (Acetylsalicylic Acid) both push the cox1 and cox2 in the same direction.
-
moderate
Celecoxib (Celebrex) + 5-Aminosalicylic Acid (Mesalamine)
5-Aminosalicylic Acid (Mesalamine) and Celecoxib (Celebrex) both push the cox1 and cox2 in the same direction.
-
moderate
Diclofenac (Voltaren) + 5-Aminosalicylic Acid (Mesalamine)
5-Aminosalicylic Acid (Mesalamine) and Diclofenac (Voltaren) both push the cox1 and cox2 in the same direction.
-
moderate
Meloxicam (Mobic) + 5-Aminosalicylic Acid (Mesalamine)
5-Aminosalicylic Acid (Mesalamine) and Meloxicam (Mobic) both push the cox1 and cox2 in the same direction.
-
moderate
Naproxen (Aleve) + 5-Aminosalicylic Acid (Mesalamine)
5-Aminosalicylic Acid (Mesalamine) and Naproxen (Aleve) both push the cox1 and cox2 in the same direction.
Serum checks 13 modeled interaction pairings for 5-aminosalicylic acid (mesalamine) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.