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MSM (Methylsulfonylmethane)

Joint Supportoral · inferred

Organosulfur compound providing bioavailable sulfur for connective tissue synthesis (collagen, keratin, glycosaminoglycans). Anti-inflammatory via NF-κB inhibition and reduction of IL-6, TNF-α, and COX-2 expression. Used for osteoarthritis (often combined with glucosamine), exercise recovery, and hair/skin/nail support. 34% elemental sulfur by weight. Rapidly absorbed orally (~80% bioavailability), distributed to all tissues. Generally well-tolerated even at high doses.

Projected serum levels — 1k mg, once daily

MSM (Methylsulfonylmethane)
MSM (Methylsulfonylmethane) modeled serum levels, 1k mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 250 500 750 1k Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1k mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 593 mg, trough ≈ 6.3 mg body load. Population-based estimate over 15 days for a 1k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Joint Support
Route modeled
Oral
Model confidence
inferred
Half-life
3.3 h
Common dose
1k mg
Suggested maximum
6k mg/day
Reference dose range
500–6k mg (single dose)
Suggested cadence
once daily

Documented interactions

  • watch
    KPV (Lys-Pro-Val) + MSM (Methylsulfonylmethane) Stacked effects

    KPV (Lys-Pro-Val) and MSM (Methylsulfonylmethane) both push the nfkb signaling in the same direction.

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    Mesalamine / 5-ASA (Lialda/Apriso/Pentasa) + MSM (Methylsulfonylmethane) Stacked effects

    Mesalamine / 5-ASA (Lialda/Apriso/Pentasa) and MSM (Methylsulfonylmethane) both push the nfkb signaling in the same direction.

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    Milk Thistle (Silymarin / Silybin) + MSM (Methylsulfonylmethane) Stacked effects

    Milk Thistle (Silymarin / Silybin) and MSM (Methylsulfonylmethane) both push the nfkb signaling in the same direction.

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    N-Acetyl Cysteine (NAC) + MSM (Methylsulfonylmethane) Stacked effects

    MSM (Methylsulfonylmethane) and N-Acetyl Cysteine (NAC) both push the endogenous sulfur pool in the same direction.

  • watch
    Sulfasalazine (Azulfidine) + MSM (Methylsulfonylmethane) Stacked effects

    MSM (Methylsulfonylmethane) and Sulfasalazine (Azulfidine) both push the nfkb signaling in the same direction.

  • watch
    Turmeric / Curcumin + MSM (Methylsulfonylmethane) Stacked effects

    MSM (Methylsulfonylmethane) and Turmeric / Curcumin both push the nfkb signaling in the same direction.

Serum checks 6 modeled interaction pairings for msm (methylsulfonylmethane) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial Kim LS et al. · Osteoarthritis and Cartilage, 2006 DOI

    Double-blind RCT (50 patients) finding MSM 3g BID for 12 weeks significantly reduced pain and improved physical function in knee OA versus placebo, with WOMAC pain scores improving by 25%.

  2. MSM supplementation attenuates inflammation and improves oxidative stress and muscle damage markers in trained men: a randomized, double-blind, placebo-controlled study Nakhostin-Roohi B et al. · Journal of Sports Medicine and Physical Fitness, 2011 DOI

    RCT in trained athletes showing MSM 50 mg/kg/day for 10 days significantly reduced muscle soreness, CRP, and oxidative stress markers after exhaustive exercise versus placebo.

2 published studies referenced in the app, each with a plain-language summary.